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Clinical Pharmacology and Therapeutics(1)
Clinical and Translational Science(1)
International Journal of Obesity(1)
Molecular Biology and Evolution(1)
OMICS A Journal of Integrative Biology(1)
Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes
ArticleAbstract: Background/objectives: Admixed populations are a resource to study the global genetic architecture oPalabras claves:Autores:Alvim I.O., Araujo G.S., Araújo N.M., Borda V., Choudhury A., Duarte Y.A.O., Dutil J., Gilman R.H., Gouveia M.H., Guio H., Hansen M.E.B., Horta B.L., Hsing A.W., Kehdy F.S.G., Leal T.P., Lima-Costa M.F., Lobo F., Luizon M.R., Lyra R., Machado M., Magalhães W.C.S., Mauricio L. Barreto, Mbulaiteye S.M., Mensah J., Michelin L.A., Naslavsky M.S., Norris S.A., O´Connor T.D., Passos-Bueno M.R., Peixoto S.V., Pereira A.C., Ramsay M., Rodrigues M.R., Santolalla M.L., Sant’Anna H.P., Scliar M.O., Tarazona-Santos E.M., Tishkoff S.A., Yamamoto G.L., Yeager M., Yeboah E., Zatz M., Zolini C.Fuentes:scopusGenomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans
ArticleAbstract: We present the distribution of CYP2D6, CYP2C9, and CYP2C19 variants and pbkp_redicted phenotypes inPalabras claves:Autores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Ferreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Michelin L.A., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusOrigin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
ArticleAbstract: While South Americans are underrepresented in human genomic diversity studies, Brazil has been a claPalabras claves:Bambuí cohort study of ageing, Latin America, Pelotas birth cohort study, Population genetics, Salvador SCAALAAutores:Araujo G.S., Beleza S., Berg D.E., Cabrera L., Costa G.N.O., Debortoli G., Duarte D., Duarte N.E., Fiaccone R.L., Figueiredo C.A.V., Ghirotto S., Gilman R.H., Gonçalves V.F., Gouveia M.H., Horimoto A.V.R., Horta B.L., Kehdy F.S.G., Leal T.P., Lima-Costa M.F., Machado M., Magalhães W.C.S., Marrero A.R., Mauricio L. Barreto, Moreira R.G., Muniz Y.C., Pereira A.C., Rodrigues L.C., Rodrigues M.R., Rodrigues-Soares F., Sant Anna H.P., Santos H.C., Scliar M.O., Silva T.M., Soares-Souza G.B., Tarazona-Santos E.M., Weissensteiner H., Yeager M., Zamudio R.Fuentes:scopusOrigins, admixture dynamics, and homogenization of the african gene pool in the americas
ArticleAbstract: The Transatlantic Slave Trade transportedmore than 9 million Africans to the Americas between the eaPalabras claves:Admixture dynamics, African Diaspora, MESTIZAJE, Transatlantic Slave TradeAutores:Alvim I.O., Aquino M.M., Araujo G.S., Araújo N.M., Bergen A.W., Borda V., Catira Bortolini M., Chanock S.J., Dean M., Furlan V., Gilman R.H., Gouveia M.H., Guio H., Horta B.L., Kehdy F.S.G., Leal T.P., Liboredo R., Lima-Costa M.F., Machado M., Magalhães W.C.S., Mauricio L. Barreto, Mbulaiteye S.M., Michelin L.A., Moreira R.G., Pereira A.C., Rocha J., Rodrigues M.R., Rodrigues-Soares F., Sant Anna H.P., Santolalla M.L., Scliar M.O., Soares-Souza G.B., Tarazona-Santos E.M., Tishkoff S.A., Yeager M., Zamudio R., Zolini C.Fuentes:scopusInterethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and pbkp_redicted drug metabolism phenotypes among 6060 ibero-and native Americans: RIBEF-CEIBA consortium report on population pharmacogenomics
ArticleAbstract: Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of gPalabras claves:Amerindians, CYP2C19, CYP2C9, CYP2D6, drug metabolism, LATIN AMERICANS, pharmacogenetics, Precision MedicineAutores:Adrián LLerena, Alvárez M., Barrantes R., Borbón-Orejuela A., Calzadilla L.R., Céspedes-Garro C., Cobaleda J., de Andrés F., Delgado R., Dorado P., Enrique Terán, Estévez-Carrizo F.E., Fcrreiro V., Francisco J.López Hernández, Fricke-Galindo I., Galaviz-Hernandez C., Garza-Ocañas L., Gilman R.H., Gouveia M.H., Grazina M., Humberto Fariñas, Jiménez-Arce G., Jung-Cook H., Lares-Aseff I., Lazalde-Ramos B.P., López-López M., Monroy-Jaramillo N., Moya G.E., Naranjo M.E.G., Ortega-Vázquez A., Ortiz-López R., Penãs-Lledó E.M., Pérez B., Pérez-Páramo Y.X., Ramírez-Roa R., Remírez D., Rodeiro I., Rodrigues-Soares F., Rojas-Martinez A., Santiago Terán, Sarmiento A.P., Scliar M.O., Sosa-Macías M.G., Tarazona-Santos E.M., Tinoco C.A., Zamudio R.Fuentes:googlescopusPopulation genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics
ArticleAbstract: PDE4B (phosphodiesterase-4B) has an important role in cancer and in pharmacology of some disorders,Palabras claves:Autores:Adrián LLerena, Balázs Z., Borda V., Galaviz-Hernandez C., Gilman R.H., Guio H., Leal T.P., Magalhães W.C.S., Mill J.G., Moreira R.G., O’Connor T.D., Pereira A.C., Rodrigues-Soares F., Santolalla M.L., Saraiva-Duarte J.M., Sosa-Macías M.G., Tarazona-Santos E.M., Zolini C.Fuentes:scopus