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Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant
ArticleAbstract: Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%–50% of noPalabras claves:covid-19, D614G, point of care testing, rapid diagnoses, SARS-COV-2Autores:Abeseabe R., Allain J.P., Amoroso G., Assennato S.M., Baker S., Barmpounakis P., Bates A., Bergamaschi L., Bermperi A., Blake E., Bousfield R., Boyle A., Bradley J.R., Briggs J.A.G., Brown N., Bucke A., Bundi P., Calder J., Canna L., Chapman D., Chatterjee K., Chiu E., Ciazynska K.A., Clark S., Collier D.A., Crucusio C., Curran M.D., Davidson F., de Jesus R., Demeris N., Domingo J., Dougan G., Elmer A., Emma Jones, Enoch D., Fabiculana M., Foster E., Frost S., Gkrania-Klotsas E., Goel N., Goodfellow I.G., Gupta R.K., Hardwick S., Hardy R., Harris J., Hewitt S., Hosmillo M., James L.C., Jose S., Kennet J., Kiss L., Knock H., Kourampa E., Kourampa J., Lehner P.J., Lyons P.A., Matheson N.J., Meadows A., Mendoza V., Meng B., Mescia F., Mlcochova P., Mynott L., Nathan J.A., O'Brien C., Overhill A., Palmar S., Pasquale C., Perales M., Phillips D., Price J., Ramenatte N., Rastall R., Ribeiro C., Ritchie A., Rowlands J., Rundell V., Saunders C., Shaw A., Sipple J., Skells R., Smith K.G.C., Sparkes D., Temperton N.J., Tordesillas H., Toshner M., Vallier A.L., Vargas P., Vergese B., Vicente I., Watson L., Weekes M.P., Williams A., Wilson M., Worsley J., Xiong X., Zerrudo J.A., Zhang H.Fuentes:scopusBrain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
ArticleAbstract: COVID-19 is associated with neurological complications including stroke, delirium and encephalitis.Palabras claves:Autoantibodies, Brain injury, covid-19, neuroinflammationAutores:Allinson K., Allison J., Alvio G., Ansaripour A., Anwar F., Ashton N.J., Baker S., Barcenas-Morales G., Bergamaschi L., Bermperi A., Betancourt A., Bhatti J., Biggs H., Bong S.H., Bower G., Bradley J.R., Breen G., Brookes K., Bucke A., Bullman B., Bullmore E.T., Bunclark K., Burnstein R.M., Butcher H., Caddy S., Calder J., Caller L., Canna L., Caputo D., Cavanagh J., Chandler M., Chatfield D.A., Chaudhry Y., Chinnery P.F., Christmas D., Clapham-Riley D., Coles A.J., Coles J.P., Cooper D., Correia M., Cossetti C., Crucusio C., Das T., Digby R.J., Doffinger R., Dunai C., Dunning J., Ebrahimi S., Edé A., Elmer A., Emma Jones, Fletcher P.C., Fonseca C., Gisslé M., Griffiths M.J., Irani S.R., Jubb A.W., Kingston N., Leibowitz M.M., Lupson V.C., Lyons P.A., Manktelow A.E., Marklund E., Menon D.K., Michael B.D., Michell A., Needham E.J., Newcombe V.F.J., Norton E.J., Openshaw P.J.M., Outtrim J.G., Pointon L., Ren A.L., Rodgers C.T., Rowe J.B., Rua C., Samanta R.J., Sithole N., Smith K.G.C., Spindler L.R.B., Stamatakis E.A., Summers C., Taams L.S., Taussig M.J., Taylor J., Valerio F., Widmer B., Williams G.B., Zetterberg H.Fuentes:scopusA thermostable, closed SARS-CoV-2 spike protein trimer
ArticleAbstract: The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant tarPalabras claves:Autores:Baker S., Baxendale H.E., Bergamaschi L., Betancourt A., Bower G., Bradley J.R., Briggs J.A.G., Bucke A., Bullman B., Butcher H., Calder J., Canna L., Caputo D., Carter A.P., Ciazynska K.A., Crucusio C., de Sa A., Dewhust E., Doffinger R., Domingo J., Dunmore B.J., Ebrahimi S., Elmer A., Emma Jones, Epping M., Fawke S., Goodfellow I.G., Graf S., Graves B., Grice G.L., Harris J., Hewitt S., Hodgson J., Hosmillo M., Huang C., Huhn O., Hunter K., James L.C., Jarvis I., Jose S., Ke Z., Kennet J., Kourampa J., Le Gresley E., Legchenko E., Li E., Lyons P.A., Marsden J., Martin J., Meadows A., Mescia F., Nathan J.A., Nice F., Omarjee O., Ovington N., O’Brien C., O’Donnell C., Papadia S., Perera M., Pointon L., Pond N., Price J., Qu K., Rastall R., Ribeiro C., Richoz N., Rowlands J., Ruffolo V., Scheres S.H.W., Sharma R., Shih J., Smith K.G.C., Stark H., Stirrups K., Sutcliffe R., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Walker N., Wood J., Wylot M., Xiong X., Zhang Y.Fuentes:scopusAge-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
ArticleAbstract: Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is littlePalabras claves:Autores:Abdullahi A., Baker S., Bergamaschi L., Betancourt A., Bower G., Bucke A., Bullman B., Bunclark K., Calder J., Canna L., Collier D.A., Cossetti C., Datir R.P., de Sa A., Domingo J., Dougan G., Dunmore B.J., Eckart E.M., Elmer A., Emma Jones, Epping M., Fawke S., Ferreira I.A.T.M., Fuller S., Gleadall N., Graf S., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Huang C., Huhn O., Hunter K., Jackson S., Jarvis I., Jose S., Josipovic M., Kennet J., Kingston N., Kotagiri P., Kourampa J., Krishna B., Legchenko E., Lehner P.J., Lewis D., Lim E.Y., Lyons P.A., Mackay M., Marsden J., Martin J., Matara C., Matheson N.J., Maxwell P., Meadows A., Meng B., Mescia F., Michael A., Nice F., Okecha G., Omarjee O., Owehand W.H., O’Brien C., O’Donnell C., Perera M., Pointon L., Pond N., Potts M., Price J., Publico C., Rastall R., Ribeiro C., Richoz N., Romashova V., Rossi S., Rowlands J., Ruffolo V., Saunders C., Sharma R., Shaw A., Shih J., Stefanucci L., Stephens J., Strezlecki M., Summers C., Sutcliffe R., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Toshner M., Touizer E., Treacy C., Turner L., Weekes M.P., Wood J., Wylot M., Yarkoni N.S.Fuentes:scopusAltered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
ArticleAbstract: The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike proteinPalabras claves:Autores:Abdullahi A., Baker S., Belén Prado-Vivar, Bernardo M. Gutierrez, Betancourt A., Bower G., Brevini T., Bucke A., Bullman B., Calder J., Canna L., Charles O.J., Cossetti C., de Sa A., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Erika B. Muñoz, Fatihi S., Fawke S., Ferreira I.A.T.M., Fuller S., Gabriel Trueba, Gerber P.P., Gleadall N., Goonawardane N., Graf S., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Huang C., Hunter K., Ikeda T., Jackson S., Jarvis I., Jose S., Juan José Guadalupe, Kemp S.A., Kennet J., Kimura I., Kingston N., Kourampa J., Krishna B., Kuramochi J., Legchenko E., Lehner P.J., Lyons P.A., Mallery D.L., Manuel Eduardo Baldeón, Martin J., Matara C., Mateo Caravajal, Matheson N.J., Maxwell P., Meadows A., Meng B., Mescia F., Michelle Grunauer Andrade, Mitsunaga S., Mónica Becerra-Wong, Nice F., Omarjee O., Ouwehand W.H., O’Brien C., O’Donnell C., Papa G., Patricio Rojas-Silva, Paul Andres Cardenas, Paul Cardenas, Perera M., Pointon L., Potts M., Price J., Publico C., Rastall R., Rathore S., Ribeiro C., Richoz N., Romashova V., Rowlands J., Ruffolo V., Saito A., Saunders C., Shaw A., Shih J., Shirakawa K., Stefanucci L., Strezlecki M., Sully Márquez, Summers C., Sutcliffe R., Takaori-Kondo A., Tan T.S., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Toshner M., Toyoda M., Treacy C., Turner L., Ueno T., Verónica Barragán, Weekes M.P., Wood J., Wylot M., Yamasoba D., Zepeda S.K.Fuentes:googlescopusLongitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
ArticleAbstract: The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assesPalabras claves:bystander CD8+ T cell, complement, covid-19, immune pathology, INTERFERÓN, recovery, SARS-COV-2, Systemic inflammation, TNF-αAutores:Allison J., Ansaripour A., Baker S., Bergamaschi L., Betancourt A., Bong S.H., Bower G., Bradley J.R., Bucke A., Bullman B., Bunclark K., Butcher H., Calder J., Calero-Nieto F.J., Canna L., Caputo D., Clapham-Riley D., Cossetti C., Coudert J.D., de Bie E.M.D.D., de Sa A., Dewhurst E., di Stefano G., Doffinger R., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fahey C., Fawke S., Fuller S., Furlong A., Gerber P.P., Gleadall N., Goodfellow I.G., Göttgens B., Graf S., Graves B., Gray J., Grenfell R., Gupta R.K., Hanson A.L., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Holmes E., Hosmillo M., Huang C., Huhn O., Hunter K., Ivers T., Jackson S., Jarvis I., Jose S., Josipovic M., Kasanicki M., Kennet J., Kingston N., Kotagiri P., Kourampa J., Laurenti E., Le Gresley E., Legchenko E., Lehner P.J., Lewis D., Linger R., Lyons P.A., Mackay M., Marioni J.C., Marsden J., Martin J., Matara C., Matheson N.J., Meadows A., Meloy S., Mende N., Mescia F., Michael A., Michel R., Morgan M.D., Muldoon F., Mwaura L., Nice F., Nicholson J.K., Petrunkina A.M., Richardson S., Ruffieux H., Saunders C., Smith K.G.C., Thaventhiran J.E.D., Toonen E.J.M., Toshner M., Turner L., Weekes M.P., Wills M.R.Fuentes:scopusSensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
ArticleAbstract: Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in somePalabras claves:Autores:Baker S., Bassi J., Bergamaschi L., Bernardo M. Gutierrez, Betancourt A., Bianchi S., Bowen J., Bower G., Bucke A., Bullman B., Calder J., Cameroni E., Canna L., Collier D.A., Cossetti C., Culap K., Datir R.P., De Marco A., de Sa A., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fawke S., Ferreira I.A.T.M., Fuller S., Garzoni C., Graf S., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Huang C., Huhn O., Hunter K., Jackson S., Jaconi S., Jarvis I., Jose S., Kemp S.A., Kennet J., Kingston N., Kourampa J., Legchenko E., Lehner P.J., Lewis D., Lyons P.A., Marsden J., Martin J., Matara C., Matheson N.J., Meadows A., Meng B., Mescia F., Nice F., Okecha G., Omarjee O., Owehand W.H., O’Brien C., O’Donnell C., Pellanda A.F., Perera M., Pinto D., Pizzuto M.S., Pointon L., Pond N., Price J., Publico C., Rastall R., Ribeiro C., Richoz N., Riva A., Romashova V., Rowlands J., Ruffolo V., Saunders C., Sharma R., Shih J., Silacci-Fregni C., Snell G., Stefanucci L., Stephens J., Strezlecki M., Summers C., Sutcliffe R., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Tortorici M.A., Toshner M., Treacy C., Walls A.C., Weekes M.P., Wood J., Wylot M., Yarkoni N.S.Fuentes:scopusSingle-cell multi-omics analysis of the immune response in COVID-19
ArticleAbstract: Analysis of human blood immune cells provides insights into the coordinated response to viral infectPalabras claves:Autores:Bacardit J., Bach K., Baker K.F., Baker S., Barnes J.L., Barr A.S., Bergamaschi L., Botting R.A., Bradley J.R., Bucke A., Bullman B., Calder J., Calero-Nieto F.J., Canna L., Coupland P., Coxhead J.M., Dann E., de Wilton A., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Engelbert J., Fawke S., Fuller S., Gardner L.C.S., Goh I., Goodfellow I.G., Gopee N., Gothe F., Graf S., Gupta R.K., Hanrath A.T., Harris J., Hess C., Hewitt S., Hodgson J., Horsfall D., Huang C., Huang N., Hunter K., Janes S.M., Jardine L., Jose S., Kania K., Kennet J., Kilich E., King H.W., Kingston N., Kiselev V.Y., Kourampa J., Kumasaka N., Legchenko E., Lehner P.J., Lindeboom R.G.H., Matara C., Mather M.W., Matheson N.J., McGrath J., Meadows A., Mende N., Mescia F., Morgan M.D., Olabi B., Owehand W.H., O’Brien C., Payne R.P., Polanski K., Price J., Prigmore E., Publico C., Rastall R., Reynolds G., Ribeiro C., Rowlands J., Ruffolo V., Saigal A., Saleh A., Sanchez-Gonzalez A., Saunders C., Schim van der Loeff I.C.D., Scott J., Smith C.M., Smith K.G.C., Spegarova J.S., Stephenson E., Summers C., Sungnak W., Thaventhiran J.E.D., Tordesillas H., Toshner M., Tuong Z.K., van Dongen S., Webb S., Weekes M.P., Wilson C., Wilson N.K., Worlock K.B., Yoshida M.Fuentes:scopusSARS-CoV-2 evolution during treatment of chronic infection
ArticleAbstract: The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for viPalabras claves:Autores:Baker S., Bergamaschi L., Bernardo M. Gutierrez, Betancourt A., Bower G., Bucke A., Bullman B., Bunclark K., Calder J., Canna L., Chandra A., Collier D.A., Cossetti C., Datir R.P., de Bie E.M.D.D., de Sa A., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fawke S., Ferreira I.A.T.M., Fuller S., Gayed S., Gleadall N., Graf S., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Hosmillo M., Huang C., Huhn O., Hunter K., Jackson S., Jahun A.S., Jarvis I., Jose S., Josipovic M., Kemp S.A., Kennet J., Kingston N., Kourampa J., Legchenko E., Lehner P.J., Lewis D., Lumb I.U., Lyons P.A., Mackay M., Marsden J., Martin J., Matara C., Matheson N.J., Meadows A., Mescia F., Mlcochova P., Nice F., Okecha G., Omarjee O., Owehand W.H., O’Brien C., O’Donnell C., Perera M., Pointon L., Pond N., Price J., Publico C., Rastall R., Rees-Spear C., Ribeiro C., Richoz N., Roberts D.J., Romashova V., Rossi S., Rowlands J., Ruffolo V., Saunders C., Sharma R., Shih J., Stefanucci L., Stephens J., Strezlecki M., Summers C., Sutcliffe R., Temperton N.J., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Weekes M.P., Wood J., Wylot M., Yarkoni N.S.Fuentes:scopusSARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
ArticleAbstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remaiPalabras claves:CP: Microbiology, DELTA, entry, fusogenicity, NTD, Omicron, Organoid, SARS-COV-2, spike, TMPRSS2Autores:Allison J., Baker S., Betancourt A., Bower G., Bucke A., Bullman B., Bunclark K., Butcher H., Calder J., Canna L., Caputo D., Choi J., Clapham-Riley D., Cossetti C., Datir R.P., de Bie E.M.D.D., de Sa A., Dewhurst E., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fawke S., Fuller S., Furlong A., Gleadall N., Graf S., Graves B., Gray J., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Huang C., Hunter K., Ivers T., Jackson S., Jarvis I., Jose S., Josipovic M., Kennet J., Kingston N., Kourampa J., Krishna B., Le Gresley E., Legchenko E., Lehner P.J., Linger R., Lyons P.A., Mackay M., Martin J., Matara C., Matheson N.J., Maxwell P., Meadows A., Meloy S., Meng B., Mescia F., Muldoon F., Nice F., O'Brien C., O'Donnell C., Omarjee O., Ovington N., Owehand W.H., Papadia S., Perera M., Phelan I., Pointon L., Potts M., Price J., Publico C., Rastall R., Ribeiro C., Richoz N., Romashova V., Rowlands J., Ruffolo V., Saunders C., Shaw A., Shih J., Stark H., Stefanucci L., Strezlecki M., Summers C., Sutcliffe R., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Weekes M.P., Wood J., Wylot M.Fuentes:scopus