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Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
ArticleAbstract: Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1Palabras claves:Dafachronic acid, Parasitology, Pharmacology, X-ray crystal structureAutores:Conneely A., Gao X., Hawdon J.M., Kliewer S.A., Lok J., Mangelsdorf D.J., Motola D.L., Ogata C., Richard J. Auchus, Sharma K.K., Suino-Powell K., Wang Z., Xu H.E., Zhou X.Fuentes:scopusWhy human cytochrome P450c21 is a progesterone 21-hydroxylase
ArticleAbstract: Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2) catalyzes the 21-hydroxylation of progestPalabras claves:Autores:Dwyer C., Gupta M.K., Mizrachi D., Richard J. Auchus, Sharma K.K., Wang Z., Xu K.Fuentes:scopusSynthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor
ArticleAbstract: The nuclear hormone receptor DAF-12 from Caenorhabditis elegans is activated by dafachronic acids, wPalabras claves:Autores:Cummins C.L., Mangelsdorf D.J., Motola D.L., Richard J. Auchus, Sharma K.K., Wang Z.Fuentes:scopus