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Cytotoxic and apoptosis-inducing effect of ent-15-oxo-kaur-16-en-19-oic acid, a derivative of grandiflorolic acid from Espeletia schultzii
ArticleAbstract: ent-Kaurenic acid and many natural derivatives of this diterpene are known to have interesting bioloPalabras claves:apoptosis, ent-5-Oxo-kaur-16-en-19-oic acid, ent-Kaurenoids, Espeletia schultzii, Espeletiinae, Frailejón, PC-3 cell lineAutores:Arvelo F.A., Galindo-Castro I., Monsalve M., Nardy Diez, Rodrigues J.R., Ruiz Y., Usubillaga A.Fuentes:googlescopusCytotoxic and proapoptotic activity of ent-16β-17α- dihydroxykaurane on human mammary carcinoma cell line MCF-7
ArticleAbstract: Here we describe the cytotoxic and proapoptotic effect of an ent-kaurane (ent-16β-17α-dihydroxykauraPalabras claves:Anticancer agents, apoptosis, BCL2, Cytotoxic activity, Ent-kaurane, Telomerase activityAutores:Alírica Isabel Suárez, Arvelo F.A., Compagnone R.S., Galindo-Castro I., Luis Ramírez J., Mendoza R., Morales A., Pérez P.Fuentes:scopusThe natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
ArticleAbstract: ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from thePalabras claves:AP-2α/Rb, apoptosis, BCL-2, E2F1, ent-16β-17α-Dihydroxykaurane (DHK), PUMAAutores:Alírica Isabel Suárez, Álvarez A., Arvelo F.A., Compagnone R.S., Galindo-Castro I., Morales A.Fuentes:scopus