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Biochemistry(2)
Clinical Cancer Research(1)
Molecular Endocrinology(1)
Molecular and Cellular Endocrinology(1)
Proceedings of the National Academy of Sciences of the United States of America(1)
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Bioquímica(4)
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scopus(6)
Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: A rationale for increasing drug exposure in castration-resistant prostate cancer
ArticleAbstract: Purpose: Treatment with abiraterone (abi) acetate prolongs survival in castration-resistant prostatePalabras claves:Autores:Chang K.H., Evaul K., Li R., Liu J., Richard J. Auchus, Sharifi N., Sharma K.K., Yoshimoto J.A.Fuentes:scopusDeoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues
Conference ObjectAbstract: Aldosterone is the principal endogenous mineralocorticoid in humans and regulates salt and water homPalabras claves:AKR1C3, COLON, Doc, Human, inactivation, Kidney, mineralocorticoidAutores:Andersson S., Lindqvist A., Penning T.M., Richard J. Auchus, Sharma K.K., Zhou X.J.Fuentes:scopusIdentification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
ArticleAbstract: Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1Palabras claves:Dafachronic acid, Parasitology, Pharmacology, X-ray crystal structureAutores:Conneely A., Gao X., Hawdon J.M., Kliewer S.A., Lok J., Mangelsdorf D.J., Motola D.L., Ogata C., Richard J. Auchus, Sharma K.K., Suino-Powell K., Wang Z., Xu H.E., Zhou X.Fuentes:scopusMinor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates
ArticleAbstract: The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydrPalabras claves:Autores:Matthew S., Peng H.M., Richard J. Auchus, Sharma K.K., Stidd D., Yoshimoto F.K., Yoshimoto J.A., Zhou Y.Fuentes:scopusWhy human cytochrome P450c21 is a progesterone 21-hydroxylase
ArticleAbstract: Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2) catalyzes the 21-hydroxylation of progestPalabras claves:Autores:Dwyer C., Gupta M.K., Mizrachi D., Richard J. Auchus, Sharma K.K., Wang Z., Xu K.Fuentes:scopusSynthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor
ArticleAbstract: The nuclear hormone receptor DAF-12 from Caenorhabditis elegans is activated by dafachronic acids, wPalabras claves:Autores:Cummins C.L., Mangelsdorf D.J., Motola D.L., Richard J. Auchus, Sharma K.K., Wang Z.Fuentes:scopus