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3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum
ArticleAbstract: 3-Nitropropionic acid (3-NP) is a neurotoxin that inhibits mitochondrial complex II and is used in aPalabras claves:3-nitropropionic acid, Calpain, CDK5, MEF2Autores:Antoni Camins, Canudas A.M., Crespo-Biel N., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusCell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
ArticleAbstract: This study was undertaken to investigate the potential role of cell cycle re-entry in an experimentaPalabras claves:apoptosis, cell cycle, Huntington's disease, StriatumAutores:Antoni Camins, Crespo-Biel N., Del Valle J., Duran-Vilaregut J., Ferrer I., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusGSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
ArticleAbstract: In the present study, we evaluated the effects of roscovitine (Rosco) and flavopiridol (Flavo), bothPalabras claves:apoptosis, Cerebellar granular cells, flavopiridol, GSK3β, RoscovitineAutores:Antoni Camins, Auladell C., de la Torre A.V., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusPI3 k/akt inhibition induces apoptosis through p38 activation in neurons
ArticleAbstract: Accumulating evidence suggests that the PI3 K/AKT pathway is a pro-survival signalling system in neuPalabras claves:Akt, BH3 only proteins, BIM, Dp5, LY294002, Neurons, p38 MAPKAutores:Antoni Camins, Auladell C., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Vázquez De La Torre A., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusRole of matrix metalloproteinase-9 (MMP-9) in striatal blood-brain barrier disruption in a 3-nitropropionic acid model of Huntington's disease
ArticleAbstract: Aim: 3-Nitropropionic acid (3-NPA) is a natural toxin that, when administered to experimental animalPalabras claves:3-nitropropionic acid, blood-brain barrier, Huntington's disease, Immunohistochemistry, Matrix metallopro teinase, StriatumAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusStudy of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons
ArticleAbstract: In the present study we focused in the PI3K/Akt pathway which plays a key role in neuronal survival.Palabras claves:BrdU, Caspase-6, Cdk5/p25, cell cycle, LY294002Autores:Antoni Camins, Auladell C., Folch J., Junyent F., Palls M., Pelegrí Gabalda C., Torre A.V.D.L., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusSystemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
ArticleAbstract: The intraperitoneal administration of 3-nitropropionic acid, which is commonly used to induce toxiciPalabras claves:apoptosis, Huntington's disease, Neurodegeneration, RAT, Striatum, TUNELAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Junyent F., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopus