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Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid
ArticleAbstract: 3-Nitropropionic acid (3-NPA) is a natural toxin that is used to induce models of Huntington's diseaPalabras claves:3-nitropropionic acid, blood-brain barrier, Evans blue, Huntington's disease, StriatumAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusAn evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis
ArticleAbstract: The neuroprotective effects of melatonin in an experimental model of aging-induced apoptosis have bePalabras claves:aging, cell cycle, Neurodegeneration, P53Autores:Antoni Camins, Pallás M., Pelegrí Gabalda C., Tajes Orduña M., Vilaplana J.Fuentes:scopusAntiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases
ReviewAbstract: The purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegPalabras claves:Alzheimer's disease, apoptosis, Cyclin-dependent kinases, Glutamate receptors, Neuronal cell death, Neuroprotective drugs. apoptosis, Parkinson's DiseaseAutores:Antoni Camins, Auladell C., Canudas A.M., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopus3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum
ArticleAbstract: 3-Nitropropionic acid (3-NP) is a neurotoxin that inhibits mitochondrial complex II and is used in aPalabras claves:3-nitropropionic acid, Calpain, CDK5, MEF2Autores:Antoni Camins, Canudas A.M., Crespo-Biel N., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusCell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
ArticleAbstract: This study was undertaken to investigate the potential role of cell cycle re-entry in an experimentaPalabras claves:apoptosis, cell cycle, Huntington's disease, StriatumAutores:Antoni Camins, Crespo-Biel N., Del Valle J., Duran-Vilaregut J., Ferrer I., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusCerebral amyloid angiopathy, blood-brain barrier disruption and amyloid accumulation in SAMP8 mice
ArticleAbstract: Cerebrovascular dysfunction and β-amyloid peptide deposition on the walls of cerebral blood vesselsPalabras claves:Alzheimer's disease, Amyloid accumulation, blood-brain barrier, Cerebral amyloid angiopathy, late-onset Alzheimer's disease, SAMP8 miceAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusGSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
ArticleAbstract: In the present study, we evaluated the effects of roscovitine (Rosco) and flavopiridol (Flavo), bothPalabras claves:apoptosis, Cerebellar granular cells, flavopiridol, GSK3β, RoscovitineAutores:Antoni Camins, Auladell C., de la Torre A.V., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusEarly amyloid accumulation in the hippocampus of SAMP8 mice
ArticleAbstract: Late-onset Alzheimer's disease (AD) is the most common form of AD appearing after 65 years of age. TPalabras claves:aging, Alzheimer's disease, Amyloid-β, Aβ40, Aβ42, AβPP, hippocampus, SAMP8, SAMR1, SenescenceAutores:Antoni Camins, Casadesús G., Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusNeuronal apoptosis in the striatum of rats treated with 3-nitropropionic acid is not triggered by cell-cycle re-entry
ArticleAbstract: Although terminally differentiated neurons lack the capacity to undergo cell division, they retain tPalabras claves:3-nitropropionic acid, apoptosis, Cell-cycle re-entry, Immunohistochemistry, NeurodegenerationAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusPI3 k/akt inhibition induces apoptosis through p38 activation in neurons
ArticleAbstract: Accumulating evidence suggests that the PI3 K/AKT pathway is a pro-survival signalling system in neuPalabras claves:Akt, BH3 only proteins, BIM, Dp5, LY294002, Neurons, p38 MAPKAutores:Antoni Camins, Auladell C., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Vázquez De La Torre A., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopus