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Clustered granules present in the hippocampus of aged mice result from a degenerative process affecting astrocytes and their surrounding neuropil
ArticleAbstract: Clusters of pathological granular structures appear and progressively increase in number with age inPalabras claves:aging, Astrocyte, Granules, hippocampus, Neo-epitope, Periodic acid-Schiff, SAMP8Autores:Antoni Camins, Cabezón I., Liberski P.P., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusEarly amyloid accumulation in the hippocampus of SAMP8 mice
ArticleAbstract: Late-onset Alzheimer's disease (AD) is the most common form of AD appearing after 65 years of age. TPalabras claves:aging, Alzheimer's disease, Amyloid-β, Aβ40, Aβ42, AβPP, hippocampus, SAMP8, SAMR1, SenescenceAutores:Antoni Camins, Casadesús G., Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusIncreased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
ArticleAbstract: SAMP8 mice show several indicative characteristics of accelerated aging and have been used to studyPalabras claves:blood-brain barrier, Confocal microscopy, hippocampus, IgG quantification, Immunohistochemistry, mouse, SAMP8, SenescenceAutores:Antoni Camins, Canudas A.M., Casadesús G., Del Valle J., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusPresence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice
ArticleAbstract: Clustered pathological granules related to a degenerative process appear and increase progressivelyPalabras claves:aging, hippocampus, Igm, Mouse ascites Golgi, Periodic acid-Schiff, SAMP8, β-AmyloidAutores:Antoni Camins, Cabezón I., Del Valle J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusTime-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice
ArticleAbstract: Senescence of the cerebrovascular system and an abnormal function of the blood-brain barrier have bePalabras claves:Alzheimer's disease, blood-brain barrier, Evans blue, SAMP8, SAMR1Autores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopus