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International Journal of Stroke(1)
New England Journal of Medicine(1)
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Associations of Early Systolic Blood Pressure Control and Outcome after Thrombolysis-Eligible Acute Ischemic Stroke: Results from the ENCHANTED Study
ArticleAbstract: Background and Purpose: In thrombolysis-eligible patients with acute ischemic stroke, there is uncerPalabras claves:Blood pressure, Hypertension, intracranial hemorrhage, Ischemic strokeAutores:Anderson C.S., Arima H., Bath P.M.W., Broderick J.P., Chalmers J., Chen G., Chen X., Delcourt C., Demchuk A.M., Donnan G.A., Durham A.C., Lavados P.M., Lee T.H., Levi C., Lindley R.I., Luca Di Tanna G., Martins S.O., Minhas J.S., Moullaali T.J., Octavio Marques Pontes-Neto, Olavarria V.V., Pandian J.D., Parsons M.W., Ricci S., Robinson T.G., Sato S., Sharma V.K., Silva-Sieger F.A., Song L., Thang N.H., Wang J.G., Wang X., Woodward M.Fuentes:scopusEffects of intensive blood pressure lowering on cerebral ischaemia in thrombolysed patients: insights from the ENCHANTED trial
ArticleAbstract: Background: Intensive blood pressure lowering may adversely affect evolving cerebral ischaemia. We aPalabras claves:Acute ischaemic stroke, Blood pressure, Brain imaging, Cerebral infarction, Clinical trial, thrombolysisAutores:Bath P.M.W., Billot L., Broderick J.P., Chalmers J., Chen C., Chen X., Delcourt C., Demchuk A.M., Donnan G.A., Lavados P.M., Levi C., Li G., Li Q., Lindley R.I., Liu L., Mair G., Martins S.O., Octavio Marques Pontes-Neto, Olavarria V.V., Ong S., Ouyang M., Parsons M.W., Robinson T.G., S Anderson C., Song L., Venturelli P.M., Wang X., Wardlaw J.M., Zhang G., Zhang L.Fuentes:scopusINTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial
ArticleAbstract: Background: Early intensive blood pressure (BP) lowering remains the most promising treatment for acPalabras claves:Care bundle, Clinical trial, Intracerebral Hemorrhage, management, Stepped-wedge cluster-randomized trial, strokeAutores:Abanto C., Anderson C.S., Arauz-Gongora A., Billot L., Chen X., Hu X., Li Q., Ma L., Octavio Marques Pontes-Neto, Ouyang M., Pandian J.D., Silva A.d., Song L., Thang N.H., Venturelli P.M., Wahab K.W., Wasay M., You C.Fuentes:scopusLow-dose versus standard-dose intravenous alteplase in acute ischemic stroke
ArticleAbstract: BACKGROUND: Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravPalabras claves:Autores:Arima H., Bath P.M.W., Billot L., Broderick J.P., Cao Y., Chalmers J., Chen G., Chen X., Demchuk A.M., Donnan G.A., Huang Y., Kim J.S., Lavados P.M., Lee T.H., Levi C., Li Q., Lindley R.I., Martins S.O., Octavio Marques Pontes-Neto, Olavarria V.V., Pandian J.D., Parsons M.W., Ricci S., Robinson T.G., Roffe C., S Anderson C., Sharma V.K., Silva-Sieger F.A., Thang N.H., Wang J.G., Wang X., Woodward M.Fuentes:scopusIntensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial
ArticleAbstract: Background: Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic trePalabras claves:Autores:Arima H., Armenis M., Bai X., Baig M.A., Bath P.M.W., Benito D., Billot L., Blacklock N., Bousser M.G., Broderick J.P., Cao Y., Carcel C., Chalmers J., Chen G., Chen R., Chen X., Cong Y., Coutts S., Cui B., Delcourt C., Demchuk A.M., Deng H., Donnan G.A., Donnelly P., Durham A.C., Fuentes-Patarroyo S.X., Glass P., Gordon P., Guo Y., Hankey G.J., Haunton V., He R., Hirakawa Y., Huang Y., Ivanova E., Jenson K., Jia H., Kim J.S., Knight E., Kong L., Kumar N.N., Kunchok A., Lavados P.M., Levi C., Li Q., Lim J.Y., Lindley R.I., Liu L., Lv J., Malavera A., Manning L., Martins S.O., Minhas J.S., Mistri A., Monaghan H., Moullaali T.J., Naidu B., Octavio Marques Pontes-Neto, Odgers E., Olavarria V.V., Parsons M.W., Ricci S., Richtering S., Robinson T.G., S Anderson C., Sandercock P., Sanders E., Sato S., Scaria A., Sharma V.K., Silva-Sieger F.A., Simes R.J., Small S., Smith P., Song L., Stapf C., Tay N., Thang N.H., Thembani E., Tucker S., Vaghasiya R., Wang J.G., Wang X., Wardlaw J.M., Winters S., Wong K.S.L., Woodward M., Wu G., Xi Z., Yang J., Yoshimura S., You S., Zhang S., Zhao H., Zhu P.Fuentes:scopusRationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2×2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment
ArticleAbstract: Rationale: Controversy exists over the optimal dose of intravenous (iv) recombinant tissue plasminogPalabras claves:Acute ischaemic stroke, Alteplase, Dose, Hypertension, Rt-PA, thrombolysisAutores:Arima H., Bath P.M.W., Broderick J.P., Chalmers J., Chen X., Demchuk A.M., Donnan G.A., Fuentes S., Huang Y., Kim J.S., Lavados P.M., Lee T.H., Levi C., Lindley R.I., Martins S.O., Nguyen T.H., Octavio Marques Pontes-Neto, Olavarria V.V., Pandian J.D., Parsons M.W., Ricci S., Robinson T.G., S Anderson C., Sharma V.K., Silva-Sieger F.A., Stapf C., Wang J.G., Woodward M.Fuentes:scopus