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Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant
ArticleAbstract: Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%–50% of noPalabras claves:covid-19, D614G, point of care testing, rapid diagnoses, SARS-COV-2Autores:Abeseabe R., Allain J.P., Amoroso G., Assennato S.M., Baker S., Barmpounakis P., Bates A., Bergamaschi L., Bermperi A., Blake E., Bousfield R., Boyle A., Bradley J.R., Briggs J.A.G., Brown N., Bucke A., Bundi P., Calder J., Canna L., Chapman D., Chatterjee K., Chiu E., Ciazynska K.A., Clark S., Collier D.A., Crucusio C., Curran M.D., Davidson F., de Jesus R., Demeris N., Domingo J., Dougan G., Elmer A., Emma Jones, Enoch D., Fabiculana M., Foster E., Frost S., Gkrania-Klotsas E., Goel N., Goodfellow I.G., Gupta R.K., Hardwick S., Hardy R., Harris J., Hewitt S., Hosmillo M., James L.C., Jose S., Kennet J., Kiss L., Knock H., Kourampa E., Kourampa J., Lehner P.J., Lyons P.A., Matheson N.J., Meadows A., Mendoza V., Meng B., Mescia F., Mlcochova P., Mynott L., Nathan J.A., O'Brien C., Overhill A., Palmar S., Pasquale C., Perales M., Phillips D., Price J., Ramenatte N., Rastall R., Ribeiro C., Ritchie A., Rowlands J., Rundell V., Saunders C., Shaw A., Sipple J., Skells R., Smith K.G.C., Sparkes D., Temperton N.J., Tordesillas H., Toshner M., Vallier A.L., Vargas P., Vergese B., Vicente I., Watson L., Weekes M.P., Williams A., Wilson M., Worsley J., Xiong X., Zerrudo J.A., Zhang H.Fuentes:scopusBrain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
ArticleAbstract: COVID-19 is associated with neurological complications including stroke, delirium and encephalitis.Palabras claves:Autoantibodies, Brain injury, covid-19, neuroinflammationAutores:Allinson K., Allison J., Alvio G., Ansaripour A., Anwar F., Ashton N.J., Baker S., Barcenas-Morales G., Bergamaschi L., Bermperi A., Betancourt A., Bhatti J., Biggs H., Bong S.H., Bower G., Bradley J.R., Breen G., Brookes K., Bucke A., Bullman B., Bullmore E.T., Bunclark K., Burnstein R.M., Butcher H., Caddy S., Calder J., Caller L., Canna L., Caputo D., Cavanagh J., Chandler M., Chatfield D.A., Chaudhry Y., Chinnery P.F., Christmas D., Clapham-Riley D., Coles A.J., Coles J.P., Cooper D., Correia M., Cossetti C., Crucusio C., Das T., Digby R.J., Doffinger R., Dunai C., Dunning J., Ebrahimi S., Edé A., Elmer A., Emma Jones, Fletcher P.C., Fonseca C., Gisslé M., Griffiths M.J., Irani S.R., Jubb A.W., Kingston N., Leibowitz M.M., Lupson V.C., Lyons P.A., Manktelow A.E., Marklund E., Menon D.K., Michael B.D., Michell A., Needham E.J., Newcombe V.F.J., Norton E.J., Openshaw P.J.M., Outtrim J.G., Pointon L., Ren A.L., Rodgers C.T., Rowe J.B., Rua C., Samanta R.J., Sithole N., Smith K.G.C., Spindler L.R.B., Stamatakis E.A., Summers C., Taams L.S., Taussig M.J., Taylor J., Valerio F., Widmer B., Williams G.B., Zetterberg H.Fuentes:scopusA thermostable, closed SARS-CoV-2 spike protein trimer
ArticleAbstract: The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant tarPalabras claves:Autores:Baker S., Baxendale H.E., Bergamaschi L., Betancourt A., Bower G., Bradley J.R., Briggs J.A.G., Bucke A., Bullman B., Butcher H., Calder J., Canna L., Caputo D., Carter A.P., Ciazynska K.A., Crucusio C., de Sa A., Dewhust E., Doffinger R., Domingo J., Dunmore B.J., Ebrahimi S., Elmer A., Emma Jones, Epping M., Fawke S., Goodfellow I.G., Graf S., Graves B., Grice G.L., Harris J., Hewitt S., Hodgson J., Hosmillo M., Huang C., Huhn O., Hunter K., James L.C., Jarvis I., Jose S., Ke Z., Kennet J., Kourampa J., Le Gresley E., Legchenko E., Li E., Lyons P.A., Marsden J., Martin J., Meadows A., Mescia F., Nathan J.A., Nice F., Omarjee O., Ovington N., O’Brien C., O’Donnell C., Papadia S., Perera M., Pointon L., Pond N., Price J., Qu K., Rastall R., Ribeiro C., Richoz N., Rowlands J., Ruffolo V., Scheres S.H.W., Sharma R., Shih J., Smith K.G.C., Stark H., Stirrups K., Sutcliffe R., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Walker N., Wood J., Wylot M., Xiong X., Zhang Y.Fuentes:scopusLongitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
ArticleAbstract: The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assesPalabras claves:bystander CD8+ T cell, complement, covid-19, immune pathology, INTERFERÓN, recovery, SARS-COV-2, Systemic inflammation, TNF-αAutores:Allison J., Ansaripour A., Baker S., Bergamaschi L., Betancourt A., Bong S.H., Bower G., Bradley J.R., Bucke A., Bullman B., Bunclark K., Butcher H., Calder J., Calero-Nieto F.J., Canna L., Caputo D., Clapham-Riley D., Cossetti C., Coudert J.D., de Bie E.M.D.D., de Sa A., Dewhurst E., di Stefano G., Doffinger R., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fahey C., Fawke S., Fuller S., Furlong A., Gerber P.P., Gleadall N., Goodfellow I.G., Göttgens B., Graf S., Graves B., Gray J., Grenfell R., Gupta R.K., Hanson A.L., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Holmes E., Hosmillo M., Huang C., Huhn O., Hunter K., Ivers T., Jackson S., Jarvis I., Jose S., Josipovic M., Kasanicki M., Kennet J., Kingston N., Kotagiri P., Kourampa J., Laurenti E., Le Gresley E., Legchenko E., Lehner P.J., Lewis D., Linger R., Lyons P.A., Mackay M., Marioni J.C., Marsden J., Martin J., Matara C., Matheson N.J., Meadows A., Meloy S., Mende N., Mescia F., Michael A., Michel R., Morgan M.D., Muldoon F., Mwaura L., Nice F., Nicholson J.K., Petrunkina A.M., Richardson S., Ruffieux H., Saunders C., Smith K.G.C., Thaventhiran J.E.D., Toonen E.J.M., Toshner M., Turner L., Weekes M.P., Wills M.R.Fuentes:scopusSingle-cell multi-omics analysis of the immune response in COVID-19
ArticleAbstract: Analysis of human blood immune cells provides insights into the coordinated response to viral infectPalabras claves:Autores:Bacardit J., Bach K., Baker K.F., Baker S., Barnes J.L., Barr A.S., Bergamaschi L., Botting R.A., Bradley J.R., Bucke A., Bullman B., Calder J., Calero-Nieto F.J., Canna L., Coupland P., Coxhead J.M., Dann E., de Wilton A., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Engelbert J., Fawke S., Fuller S., Gardner L.C.S., Goh I., Goodfellow I.G., Gopee N., Gothe F., Graf S., Gupta R.K., Hanrath A.T., Harris J., Hess C., Hewitt S., Hodgson J., Horsfall D., Huang C., Huang N., Hunter K., Janes S.M., Jardine L., Jose S., Kania K., Kennet J., Kilich E., King H.W., Kingston N., Kiselev V.Y., Kourampa J., Kumasaka N., Legchenko E., Lehner P.J., Lindeboom R.G.H., Matara C., Mather M.W., Matheson N.J., McGrath J., Meadows A., Mende N., Mescia F., Morgan M.D., Olabi B., Owehand W.H., O’Brien C., Payne R.P., Polanski K., Price J., Prigmore E., Publico C., Rastall R., Reynolds G., Ribeiro C., Rowlands J., Ruffolo V., Saigal A., Saleh A., Sanchez-Gonzalez A., Saunders C., Schim van der Loeff I.C.D., Scott J., Smith C.M., Smith K.G.C., Spegarova J.S., Stephenson E., Summers C., Sungnak W., Thaventhiran J.E.D., Tordesillas H., Toshner M., Tuong Z.K., van Dongen S., Webb S., Weekes M.P., Wilson C., Wilson N.K., Worlock K.B., Yoshida M.Fuentes:scopusSARS-CoV-2 evolution during treatment of chronic infection
ArticleAbstract: The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for viPalabras claves:Autores:Baker S., Bergamaschi L., Bernardo M. Gutierrez, Betancourt A., Bower G., Bucke A., Bullman B., Bunclark K., Calder J., Canna L., Chandra A., Collier D.A., Cossetti C., Datir R.P., de Bie E.M.D.D., de Sa A., Domingo J., Dougan G., Dunmore B.J., Elmer A., Emma Jones, Epping M., Fawke S., Ferreira I.A.T.M., Fuller S., Gayed S., Gleadall N., Graf S., Grenfell R., Harris J., Hess C., Hewitt S., Hinch A., Hodgson J., Hosmillo M., Huang C., Huhn O., Hunter K., Jackson S., Jahun A.S., Jarvis I., Jose S., Josipovic M., Kemp S.A., Kennet J., Kingston N., Kourampa J., Legchenko E., Lehner P.J., Lewis D., Lumb I.U., Lyons P.A., Mackay M., Marsden J., Martin J., Matara C., Matheson N.J., Meadows A., Mescia F., Mlcochova P., Nice F., Okecha G., Omarjee O., Owehand W.H., O’Brien C., O’Donnell C., Perera M., Pointon L., Pond N., Price J., Publico C., Rastall R., Rees-Spear C., Ribeiro C., Richoz N., Roberts D.J., Romashova V., Rossi S., Rowlands J., Ruffolo V., Saunders C., Sharma R., Shih J., Stefanucci L., Stephens J., Strezlecki M., Summers C., Sutcliffe R., Temperton N.J., Thaventhiran J.E.D., Tilly T., Tong Z., Tordesillas H., Toshner M., Treacy C., Turner L., Weekes M.P., Wood J., Wylot M., Yarkoni N.S.Fuentes:scopus