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European Journal of Clinical Pharmacology(2)
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Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences(1)
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Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection
ArticleAbstract: A rapid high-performance liquid chromatographic method has been developed for the simultaneous deterPalabras claves:Clozapine, N-desmethyl clozapineAutores:Adrián LLerena, Berecz R., De la Rubia A., Norberto M.Fuentes:scopusDetermination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients
ArticleAbstract: A rapid high-performance liquid chromatographic method is described for the simultaneous determinatiPalabras claves:Fluoxetine, NorfluoxetineAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Dorado P., González A.P., Jesus Norberto M.Fuentes:scopusEffect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes
ArticleAbstract: Sixteen hospitalized white European Spanish psychiatric patients treated with thioridazine alone werPalabras claves:CYP2D6, debrisoquine, Inhibition, ThioridazineAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P., Fernández-Salguero P.Fuentes:scopusNo effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients [2]
OtherAbstract:Palabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusLow frequency of CYP2D6 poor metabolizers among schizophrenia patients
ArticleAbstract: CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The present studyPalabras claves:Autores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusUse of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity
ArticleAbstract: Thioridazine is metabolized in humans by CYP2D6 to mesoridazine, which is an active metabolite. TwoPalabras claves:CYP2D6, High-pressure liquid chromatography, pharmacogenetics, Therapeutic drug monitoring (TDM), ThioridazineAutores:Adrián LLerena, Benitez Rodriguez J., Berecz R., De la Rubia A., Norberto M.Fuentes:scopusQTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients
ArticleAbstract: Thioridazine cardiotoxicity has been associated with a prolonged heart-rate corrected QT (QTc) interPalabras claves:CYP2D6, debrisoquine, QTc lengthening, ThioridazineAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopusRelationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients
ArticleAbstract: Background: Around seven percent of Caucasians are poor metabolizers of cytochrome P450, CYP2D6 duePalabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopusRelationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients
ArticleAbstract: The implication of cytochrome P450 CYP2D6 enzyme activity in the metabolism of the antipsychotic druPalabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Degrell I., Dorado P., Gómez J., Kellermann M.Fuentes:scopusRelevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients
Conference ObjectAbstract: Aims: The CYP2D6 -1584C>G (rs1080985) polymorphism has been identified as another major factor for CPalabras claves:Antipsychotic drugs, CYP2D6, Mesoridazine, Phenotiazines, ThioridazineAutores:Adrián LLerena, De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopus