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scopus(13)
Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient
ArticleAbstract: A 30-year-old male patient with paranoid schizophrenia was on clozapine therapy for more than five yPalabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Degrell I., Glaub T., Kellermann M.Fuentes:scopusDetermination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients
ArticleAbstract: A rapid high-performance liquid chromatographic method is described for the simultaneous determinatiPalabras claves:Fluoxetine, NorfluoxetineAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Dorado P., González A.P., Jesus Norberto M.Fuentes:scopusEffect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes
ArticleAbstract: Sixteen hospitalized white European Spanish psychiatric patients treated with thioridazine alone werPalabras claves:CYP2D6, debrisoquine, Inhibition, ThioridazineAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P., Fernández-Salguero P.Fuentes:scopusHigh-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients
ArticleAbstract: Background: Aripiprazole (ARI) is an antipsychotic drug that is metabolized to dehydroaripiprazole (Palabras claves:Aripiprazole, CYP2D6, Dehydroaripiprazole, High-performance liquid chromatography, Psychiatric patientsAutores:Adrián LLerena, de Andrés F., De la Rubia A., Dorado P., Gonz Ález A., Gonz Ález I., Naranjo M.E.G., Peñ As-Lledó E.Fuentes:scopusIncreased use of second generation antipsychotic drugs in primary care: Potential relevance for hospitalizations in schizophrenia patients
ArticleAbstract: Aim: To analyze the changes in the prescribing pattern of antipsychotic drugs in primary care in ExtPalabras claves:Antipsychotic, drug utilization, Hospitalization, pharmacoepidemiology, Primary Health Care, SchizophreniaAutores:Adrián LLerena, Cáceres M.C., De la Rubia A., Penãs-Lledó E.M.Fuentes:scopusLow frequency of CYP2D6 poor metabolizers among schizophrenia patients
ArticleAbstract: CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The present studyPalabras claves:Autores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusUse of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity
ArticleAbstract: Thioridazine is metabolized in humans by CYP2D6 to mesoridazine, which is an active metabolite. TwoPalabras claves:CYP2D6, High-pressure liquid chromatography, pharmacogenetics, Therapeutic drug monitoring (TDM), ThioridazineAutores:Adrián LLerena, Benitez Rodriguez J., Berecz R., De la Rubia A., Norberto M.Fuentes:scopusQTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy
OtherAbstract:Palabras claves:debrisoquine, Haloperidol, QTcAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopusQTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients
ArticleAbstract: Thioridazine cardiotoxicity has been associated with a prolonged heart-rate corrected QT (QTc) interPalabras claves:CYP2D6, debrisoquine, QTc lengthening, ThioridazineAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopusRelationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients
ArticleAbstract: Background: Around seven percent of Caucasians are poor metabolizers of cytochrome P450, CYP2D6 duePalabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P.Fuentes:scopus