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Antitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2)
ArticleAbstract: Protein Kinase (casein kinase 2, CK2) is a serine-threonine kinase that is frequently dysregulated iPalabras claves:Autores:Acevedo B.E., Alonso D.F., Falcón-Cama V., López-Mola E., Mendoza O., Perea-Rodríguez S.E., Puchades Y., Reyes O., Santiago Nelson Vispo, Santos-Savio A., Silva R., Torrens I.Fuentes:scopusA modified variant of human Interleukin-15 as a novel antigen for active immunotherapy in rheumatoid arthritis
ReviewAbstract: Interleukin (IL)-15 is a pro-inflammatory cytokine that plays a crucial role in the pathogenesis ofPalabras claves:IL-15, Immunization, neutralizing antibodies, non-human primates, Rheumatoid ArthritisAutores:Alexey Llópiz-Arzuaga, Arrieta C.A., Besada-Pérez V., Castro-Velazco J., Eugenio Hardy, Geronimo H., Guillén-Nieto G.E., Martínez K., Martínez-Castillo R., Morera-Díaz Y., Moro A., Perea-Rodríguez S.E., Puente P., Ramos Y., Rodríguez-Álvarez Y., Santos-Savio A., Silva R., Vázquez M.Fuentes:scopusActive immunization with human interleukin-15 induces neutralizing antibodies in non-human primates
ArticleAbstract: Background: Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune andPalabras claves:Alum, CTLL-2 cells, Cytokine, IL-15, Immunization, Neutralizing Abs, non-human primatesAutores:Besada-Pérez V., Castro-Velazco J., Chico-Capote A., Eugenio Hardy, Gerónimo-Pérez H., Martínez-Castillo R., Martínez-Cordovez K., Morera-Díaz Y., Puente-Pérez P., Rodríguez-Álvarez Y., Santos-Savio A.Fuentes:scopusExpression and folding of an interleukin-2-proinsulin fusion protein and its conversion into insulin by a single step enzymatic removal of the C-peptide and the N-terminal fused sequence
ArticleAbstract: We report the expression in E. coli of a proinsulin fusion protein carrying a modified interleukin-2Palabras claves:Enzymatic processing, Proinsulin folding, Recombinant insulinAutores:Besada-Pérez V., Castellanos‐Serra L., Eugenio Hardy, Falcón-Cama V., Fernandez C., Gonzalez M., Herrera L., Perez G., Santiago Nelson Vispo, Santos-Savio A., Silva A., Ubieta R.Fuentes:scopusDisplaying human interleukin-2 on the surface of bacteriophage
ArticleAbstract: Previous attempts to produce active human Interleukin-2 (hIL-2) in E. coli have failed, due to its aPalabras claves:Interleukin-2, pelB, phage display, Secretion in E. coliAutores:Araña M.J., Callejo M., Chinea G., Gavilondo J.V., Ojalvo A.G., Santiago Nelson Vispo, Santos-Savio A.Fuentes:scopusObtention and characterization of the recombinant simian Interleukin-15 in Escherichia coli for the preclinical assessment of an IL-15-based therapeutic vaccine
ArticleAbstract: Recombinant simian IL-15 (siIL-15) was obtained for the preclinical assessment of an anti-human IL-1Palabras claves:CTLL-2 and Kit 225 cells, E. coli, in vitro proliferation assays, Protein, recombinant siIL-15, VaccineAutores:Alexey Llópiz-Arzuaga, Besada-Pérez V., García-Lines D., Martínez-Cordovez K., Ramos-Gómez Y., Rodríguez-Álvarez Y., Santos-Savio A.Fuentes:googlescopusIdentification of the first antagonist peptide that inhibits biological effects of interleukin-15
ArticleAbstract: Interleukin-15 (IL-15) is a pro-inflammatory cytokine that is expressed in several autoimmune and inPalabras claves:Alpha receptor, antagonist, Cytokine, IL-15, peptideAutores:Alexey Llópiz-Arzuaga, Altruda F., Ancisar J.A., Arrieta C.A., Cabrales A., Chico A., Estévez M., Garay H.E., Geronimo H., Guillén-Nieto G.E., Machado A.C., Noda J., Ojeda M., Perea-Rodríguez S.E., Reyes O., Rodríguez-Álvarez Y., Sánchez A., Santos-Savio A., Silengo L., Suaréz J., Vázquez M.Fuentes:googlescopusImmunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15
ArticleAbstract: Background: Interleukin (IL)-15 is a proinflammatory T-cell growth factor overexpressed in several aPalabras claves:African green monkeys, CTLL-2 cells, IL-15, IL-15 D8SQ108S, neutralizing antibodies, vaccine candidateAutores:Alexey Llópiz-Arzuaga, Batista-Roche L.G., Castro-Velazco J., Martínez-Castillo R., Puente-Pérez P., Rodríguez-Álvarez Y., Santos-Savio A.Fuentes:googlescopus