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A bioinformatics study of structural perturbation of 3CL-protease and the HR2-domain of SARS-CoV-2 induced by synergistic interaction with ivermectins
ArticleAbstract: The pandemic caused by SARS-CoV-2 forces drug research to combat it. Ivermectin, an FDA approved antPalabras claves:covid-19, Ivermectin, Molecular docking, molecular dynamics, SARS-COV-2Autores:Alvarado Y.J., González-Paz L.A., Joan R. Vera V., Joan Vera-Villalobos, José Luis Paz, Lossada C.A., Luis S. Moncayo, Pérez A.E., Portillo E., Romero F., San-Blas E.Fuentes:googlescopusCharacterization of the tracrARN-<inf>DR</inf> ARN genetic complex associated with the CRISPR-Cas9 system of the phytosymbiont Acholeplasma palmae: biotechnological interest
ArticleAbstract: The CRISPR-Cas9 technology used in plant biotechnology is based on the use of Cas9 endonucleases toPalabras claves:bioinformatics, Molecular docking, mycoplasma, transactivatorAutores:Arcos D., Castro A., Centanaro P., Cristina Maldonado, Diego Vaca, González-Paz L.A., Lossada C.A., Luis S. Moncayo, Pérez A.E.Fuentes:scopusComparative analysis of crispr-cas systems in vibrio and photobacterium genomes of high influence in aquaculture production
ArticleAbstract: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs), together with cas genes, constiPalabras claves:Aquaculture, Bioinformatic, CRISPR-CAS, Phagotherapy, VibrionaceaeAutores:Alvarado Y.J., Antequera L., Arcos D., Castro A., Centanaro P., Fernández-Materán F.V., González-Paz L.A., Joan Vera-Villalobos, José Luis Paz, Lossada C.A., Luis S. Moncayo, Parra A.E., Parra M.M., Pérez A.E., Romero F.Fuentes:scopusComparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors
ArticleAbstract: Cellular susceptibility to SARS-CoV-2 infection in the respiratory tract has been associated with thPalabras claves:Cell lines, Cell susceptibility, docking, Macromolecular crowding, Viral spikeAutores:Alvarado M.J., Alvarado Y.J., Fernando Javier Torres, González-Paz L.A., Hurtado-León M.L., Jeffreys L.N., Joan R. Vera V., Joan Vera-Villalobos, José Luis Paz, Loroño M.A., Lossada C.A.Fuentes:googlescopusComparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach
ArticleAbstract: The SARS-CoV-2 pandemic has accelerated the study of existing drugs. The mixture of homologs calledPalabras claves:Avermectin, covid-19, Ivermectin, Molecular docking, Molecular dynamic, SARS-COV-2Autores:Alvarado Y.J., Fernández-Materán F.V., González-Paz L.A., Hurtado-León M.L., Jeffreys L.N., Joan R. Vera V., Joan Vera-Villalobos, José Luis Paz, Loroño M.A., Lossada C.A.Fuentes:googlescopusComparison of the molecular coupling of the PLX4032 drug and the RNP CRISPR/CPF1 biopharmaceitical targeted to the metastatic melanoma type BRAF-V600E
OtherAbstract:Palabras claves:Autores:Alvarado Y.J., Bastidas M., González-Paz L.A., Lossada C.A., Luis S. Moncayo, Parra M.M., Pérez A.E., Sierra C.Fuentes:scopusBiological significance of the thermodynamic stability of crispr structures associated with unconventional functions
ArticleAbstract: The clustered regularly interspaced short palindromic repeats (CRISPR) are genetic sequences that coPalabras claves:CRISPR, MFE, transcriptionAutores:Alvarado Y.J., Fernández-Materán F.V., González-Paz L.A., Joan Vera-Villalobos, José Luis Paz, Lossada C.A., Luis S. Moncayo, Parra M.M., Pérez A.E., Portillo E., Romero F.Fuentes:scopusBiomedical importance of the thermodynamics of the crispr-cas system associated with quorum sensing and cystic fibrosis in pseudomonas aeruginosa
ArticleAbstract:Palabras claves:Autores:Alvarado Y.J., González-Paz L.A., Lossada C.A., Luis S. Moncayo, Montiel M., Parra M.M., Pérez A.E., Sierra C.Fuentes:scopusCan Non-steroidal Anti-inflammatory Drugs Affect the Interaction Between Receptor Binding Domain of SARS-COV-2 Spike and the Human ACE2 Receptor? A Computational Biophysical Study
ArticleAbstract: SARS-CoV-2 has caused millions of infections and more than 600,000 deaths worldwide. Despite the larPalabras claves:covid-19, Molecular docking, molecular dynamics, NSAIDS, SARS-COV-2Autores:Alvarado Y.J., Fernández-Materán F.V., González-Paz L.A., Joan Vera-Villalobos, José Luis Paz, Lossada C.A.Fuentes:scopusInteraction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT
ArticleAbstract: The COVID-19 pandemic has accelerated the study of drugs, most notably ivermectin and more recentlyPalabras claves:ANM, covid-19, GNM, Volume fluctuation, Volume Molar, VoronoiAutores:Alvarado Y.J., Fernando Javier Torres, González-Paz L.A., Hurtado-León M.L., Jeffreys L.N., Joan Vera-Villalobos, José Luis Paz, Loroño M.A., Lossada C.A., Olivarez Y., Vera E., Vivas A.Fuentes:scopus