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scopus(6)
A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery
ArticleAbstract: Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, couPalabras claves:Autores:Alcaide-German M.L., Garcia-Fernandez L.F., Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A.Fuentes:scopusLack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
ArticleAbstract: Hypoxia-inducible factors (HIF) belong to an evolutionary conserved family of transcription factors,Palabras claves:Autores:Alfranca A., Álvarez-Tejado M., Aragonés J., Manuel Ortiz de Landázuri, Peso L.D., Vara A.Fuentes:scopusHypoxia inducible factor 1-alpha (hif-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival
ArticleAbstract: Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delayPalabras claves:Autores:Aguado-Fraile E., Alegre L., Blanco-Sánchez I., Conde E., Garcia-Bermejo M.L., Jiménez C., Liaño F., López-Cabrera M., Manuel Ortiz de Landázuri, Ordóñez A., Peso L.D., Ponte B., Ramos E., Sáenz-Morales D., Sáiz A., Sanchez-Tomero J.A., Selgas R.Fuentes:scopusIdentification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
ArticleAbstract: HIFs [hypoxia-inducible (transcription) factors] are essential for the induction of an adaptive genePalabras claves:EGL nine homologue (EGLN), Hypoxia, Hypoxia-inducible factor (HIF), Oxygen-degradation domain (ODD), Proline hydroxylase domain (PHD), Von Hippel-Lindau protein (VHL protein)Autores:Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A., Villar D.Fuentes:scopusSpecific Oncolytic Effect of a New Hypoxia-Inducible Factor-Dependent Replicative Adenovirus on von Hippel-Lindau-Defective Renal Cell Carcinomas
ArticleAbstract: Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are responsible for a hebkp_reditaryPalabras claves:Autores:Aragonés J., Castellanos M.C., Cuevas Y., Esteban M.A., Hernández-Alcoceba R., Manuel Ortiz de Landázuri, Martin-Puig S., Naranjo-Suárez S., Peso L.D.Fuentes:scopusTargeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: The METOXIA consortium
ReviewAbstract: The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of which treaPalabras claves:Bioreductive compounds, cancer-treatment resistance, carbonic anhydrase inhibitors, dual-activity compounds, non-invasive oxygen detection, targets for new treatmentAutores:Ahmed A., Alsner J., Ashcroft M., Buffa F.M., Busk M., Calzada M.J., Cao Y., Chiche J., Cojocari D., Dubois L., Ebbesen P., Flamm H., Flatmark K., Gieling R.G., Görlach A., Haider S., Harris A.L., Jobst G., Kieninger J., Koritzinsky M., Kunkler I.H., Lambin P., Langdon S.P., Lyng H., Manuel Ortiz de Landázuri, Marchiq I., Mazure N., Meehan J., Moser I., Mujcic H., Overgaard J., Parks S., Pastorekova S., Peso L.D., Pettersen E.O., Pouyssegur J., Ree A.H., Rouschop K.M., Scozzafava A., Singleton D.C., Supuran C.T., Toustrup K., Urban G., Ward C., Weltin A., Williams K.J., Wouters B.G.Fuentes:scopus