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Accumulation of hypoxia-inducible factor-1α through a novel electrophilic, thiol antioxidant-sensitive mechanism
ArticleAbstract: 15-deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2) is a peroxisome-activated proliferator receptor-γ (PPARγPalabras claves:15-deoxy-Δ prostaglandin J 12,14 2, Electrophilic, Hypoxia inducible factor, Proximal tubular cells, Reactive oxygen species, Thiol groupsAutores:Arenas I., Castellanos C., Conde I., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G., Peso L.D.Fuentes:scopusLack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
ArticleAbstract: Hypoxia-inducible factors (HIF) belong to an evolutionary conserved family of transcription factors,Palabras claves:Autores:Alfranca A., Álvarez-Tejado M., Aragonés J., Manuel Ortiz de Landázuri, Peso L.D., Vara A.Fuentes:scopusHypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells. Protective role in apoptosis
ArticleAbstract: Hypoxia is a common environmental stress that influences signaling pathways and cell function. SeverPalabras claves:Autores:Álvarez-Tejado M., Carrera A.C., Jiménez C., Manuel Ortiz de Landázuri, Naranjo-Suárez S., Peso L.D.Fuentes:scopusHypoxia inducible factor 1-alpha (hif-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival
ArticleAbstract: Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delayPalabras claves:Autores:Aguado-Fraile E., Alegre L., Blanco-Sánchez I., Conde E., Garcia-Bermejo M.L., Jiménez C., Liaño F., López-Cabrera M., Manuel Ortiz de Landázuri, Ordóñez A., Peso L.D., Ponte B., Ramos E., Sáenz-Morales D., Sáiz A., Sanchez-Tomero J.A., Selgas R.Fuentes:scopusHypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1
ArticleAbstract: When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production thrPalabras claves:Autores:Cifuentes D., Cuevas Y., Garcia-Bermejo M.L., Garcia-Rocha M., Guinovart J., Manuel Ortiz de Landázuri, Ordóñez A., Ortiz-Barahona A., Pescador N., Peso L.D., Saez-Morales D., Vazquez S.N., Villar D.Fuentes:scopus