Mostrando 5 resultados de: 5
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Journal of Biological Chemistry(2)
Biochemical Journal(1)
Cellular Signalling(1)
Journal of Enzyme Inhibition and Medicinal Chemistry(1)
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scopus(5)
Accumulation of hypoxia-inducible factor-1α through a novel electrophilic, thiol antioxidant-sensitive mechanism
ArticleAbstract: 15-deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2) is a peroxisome-activated proliferator receptor-γ (PPARγPalabras claves:15-deoxy-Δ prostaglandin J 12,14 2, Electrophilic, Hypoxia inducible factor, Proximal tubular cells, Reactive oxygen species, Thiol groupsAutores:Arenas I., Castellanos C., Conde I., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G., Peso L.D.Fuentes:scopusDown-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation
ArticleAbstract: Cellular responses to low oxygen tension are mediated, at least in part, by the activation of the hyPalabras claves:Autores:Álvarez-Tejado M., Castellanos M.C., Manuel Ortiz de Landázuri, Naranjo-Suárez S., Peso L.D., Vara A.Fuentes:scopusHypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells. Protective role in apoptosis
ArticleAbstract: Hypoxia is a common environmental stress that influences signaling pathways and cell function. SeverPalabras claves:Autores:Álvarez-Tejado M., Carrera A.C., Jiménez C., Manuel Ortiz de Landázuri, Naranjo-Suárez S., Peso L.D.Fuentes:scopusIdentification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
ArticleAbstract: HIFs [hypoxia-inducible (transcription) factors] are essential for the induction of an adaptive genePalabras claves:EGL nine homologue (EGLN), Hypoxia, Hypoxia-inducible factor (HIF), Oxygen-degradation domain (ODD), Proline hydroxylase domain (PHD), Von Hippel-Lindau protein (VHL protein)Autores:Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A., Villar D.Fuentes:scopusTargeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: The METOXIA consortium
ReviewAbstract: The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of which treaPalabras claves:Bioreductive compounds, cancer-treatment resistance, carbonic anhydrase inhibitors, dual-activity compounds, non-invasive oxygen detection, targets for new treatmentAutores:Ahmed A., Alsner J., Ashcroft M., Buffa F.M., Busk M., Calzada M.J., Cao Y., Chiche J., Cojocari D., Dubois L., Ebbesen P., Flamm H., Flatmark K., Gieling R.G., Görlach A., Haider S., Harris A.L., Jobst G., Kieninger J., Koritzinsky M., Kunkler I.H., Lambin P., Langdon S.P., Lyng H., Manuel Ortiz de Landázuri, Marchiq I., Mazure N., Meehan J., Moser I., Mujcic H., Overgaard J., Parks S., Pastorekova S., Peso L.D., Pettersen E.O., Pouyssegur J., Ree A.H., Rouschop K.M., Scozzafava A., Singleton D.C., Supuran C.T., Toustrup K., Urban G., Ward C., Weltin A., Williams K.J., Wouters B.G.Fuentes:scopus