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Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase
ArticleAbstract: Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoanPalabras claves:Autores:Česnek M., David A. Terán, Guddat L.W., Hocková D., Keough D.T., Naesens L., Zíková A.Fuentes:scopusCrystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP
ArticleAbstract: The 6-oxopurine phosphoribosyltransferases (PRTs) are drug targets for the treatment of parasitic diPalabras claves:6-oxopurine phosphoribosyltransferase, GMP, IMP, purine salvage, Trypanosoma brucei, XMPAutores:David A. Terán, Doleželová E., Guddat L.W., Hocková D., Keough D.T., Zíková A.Fuentes:scopusEvaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery
ArticleAbstract: Due to toxicity and compliance issues and the emergence of resistance to current medications new druPalabras claves:Autores:David A. Terán, Doleželová E., Gahura O., Guddat L.W., Hocková D., Keough D.T., Kotrbová Z., Procházková M., Špaček P., Zíková A.Fuentes:scopus