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Chemical platforms for peptide vaccine constructs
Book PartAbstract: Knowledge of the sequences and structures of proteins from pathogenic microorganisms has been put toPalabras claves:Chemical approaches, MAPS, Peptide epitopes, Synthesis, VaccineAutores:Alberício F., B. G. De la Torre, Cherkupally P., Govender T., Kruger H.G., Ramesh S.Fuentes:scopusCombining solid phase synthesis and chromatographic purification for efficient peptide manufacture
ArticleAbstract: In recent years, peptides have gained an important position in the drug arena for a variety of treatPalabras claves:Oligos-peptides, Peptide purification, Peptide synthesis, Polystyrene resins, Solid phase peptide synthesisAutores:Alberício F., B. G. De la Torre, Basso A., Musaimi O.A.L., Serban S., Summers B.D.Fuentes:scopusBioconjugation through Mesitylene Thiol Alkylation
ArticleAbstract: The design and generation of complex multifunctional macromolecular structures by bioconjugation isPalabras claves:Autores:Alberício F., Cuevas C., Domínguez J.M., Hortensia Rodriguez Cabrera, Pérez-Chacon G., Ramos-Tomillero I., Sánchez‐Madrid F., Somovilla-Crespo B., Zapata J.M.Fuentes:googlescopusAn improved and efficient strategy for the total synthesis of a colistin-like peptide
ArticleAbstract: Polymyxins have re-emerged as the last-line therapy for treatment against extremely multi-drug resisPalabras claves:Antimicrobial peptide, colistin, Convergent method, SynthesisAutores:Alberício F., B. G. De la Torre, Govender T., Kruger H.G., Ramesh S.Fuentes:scopusAnalytical methodologies to assure successful peptide synthesis when utilizing polystyrene/DVB resins
ArticleAbstract: Solid-phase peptide synthesis has become an important technique as the method of choice to deliver hPalabras claves:Fluorenylmethoxycarbonyl (Fmoc), Functionalization, MORPHOLOGY, Peer Reviewed, Polystyrene resins, Solid support, Solid-phase peptide synthesis, swellingAutores:Al Musaimi O., Alberício F., Alhassan M., B. G. De la Torre, Basso A., Serban S., Summers B.D.Fuentes:scopus2-Methoxy-4-methylsulfinylbenzyl Alcohol as a Safety-Catch Linker for the Fmoc/ tBu Solid-Phase Peptide Synthesis Strategy
ArticleAbstract: Fmoc and Boc group are the two main groups used to protect the α-amino function in Solid-Phase PeptiPalabras claves:Autores:Alberício F., B. G. De la Torre, Nandhini K.P.Fuentes:scopusA convenientmicrowave-enhanced solid-phase synthesis of short chain N-methyl-rich peptides
ArticleAbstract: Structural modification of the peptide backbone via N-methylation is a powerful tool to modulate thePalabras claves:Fmoc-N-methyl amino acids, MICROWAVE, Solid-phase peptide synthesisAutores:Alberício F., Hortensia Rodriguez Cabrera, Suárez Navarro M.Fuentes:scopusA native mass spectrometry platform identifies HOP inhibitors that modulate the HSP90-HOP protein-protein interaction
ArticleAbstract: Herein we describe a native mass spectromery protein-peptide model as a competent surrogate for thePalabras claves:Autores:Alberício F., Alhassan M., B. G. De la Torre, Clarke D.J., Edkins A.L., Mackay C.L., Makhubu M.P., Mateos-Jiménez M., Müller R., Vaaltyn M.C., Veale C.G.L.Fuentes:scopusA novel protecting/activating strategy for β-hydroxy acids and its use in convergent peptide synthesis
ArticleAbstract: (Chemical Equation Presented) β-Hydroxy acids were reacted with hexafluoroacetone and carbodiimidesPalabras claves:Autores:Alberício F., Burger K., Jan Spengler, Royo M., Ruíz-Rodríguez J., Winter M., Yraola F.Fuentes:googlescopusCrystal structure, spectroscopic studies and theoretical studies of thiobarbituric acid derivatives: understanding the hydrogen-bonding patterns
ArticleAbstract: In addition to their wide-ranging applications in the pharmaceutical industry, thiobarbituric acid (Palabras claves:Crystal structure, DFT calculations, IR spectroscopy, Thiobarbituric acid, Transition state, UV spectroscopy, X-ray crystallographyAutores:Alberício F., Almarhoon Z.M., B. G. De la Torre, El-Faham A., Noki S., Sharma A., Zamisa S.J.Fuentes:scopus