Mostrando 10 resultados de: 18
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PLoS ONE(4)
Current Topics in Medicinal Chemistry(2)
Journal of Ethnopharmacology(2)
ACS Chemical Neuroscience(1)
Bioorganic and Medicinal Chemistry Letters(1)
Área temáticas
Farmacología y terapéutica(9)
Bioquímica(4)
Fisiología humana(4)
Enfermedades(3)
Microorganismos, hongos y algas(3)
Anti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, zebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
ArticleAbstract: Ethnopharmacological relevance: Epilepsy is one of the major chronic diseases that does not have a cPalabras claves:Epilepsy, Pleiocarpamine, Rauverine H, Rauvolfia caffra, zebrafishAutores:Chen W., Chipiti T., Crawford A.D., Enslin G.M., María Lorena Cordero-Maldonado, Sandasi M., Van Heerden F.R., Veale C.G.L., Viljoen A.M.Fuentes:scopusAnticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
ArticleAbstract: Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional mediciPalabras claves:Ar-turmerone, Bisabolene sesquiterpenoids, curcuma longa, Mouse PTZ model, Pentylenetetrazole, Turmeric, turmeric oil, zebrafish PTZ model, α,β-Turmerone, α-AtlantoneAutores:Adriana Orellana-Paucar, Afrikanova T., Alen J., Crawford A.D., De Borggraeve W., De Witte P.A.M., Esguerra C.V., Fabián León-Tamariz, Maes J., Serruys A.S.K., Wilches IsabelFuentes:googlescopus2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes
ArticleAbstract: The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liPalabras claves:2-Octadecynoic acid, Acetylenic fatty acids, Blood stage, Liver stage, MALARIA, plasmodium, Type II fatty acid synthaseAutores:Andricopulo A.D., Bwalya A.G., Carballeira N.M., Crawford A.D., Guido R.V.C., Itoe M.A., Kaiser M., María Lorena Cordero-Maldonado, Mota M.M., Tasdemir D.Fuentes:scopusA phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling
ArticleAbstract: Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation andPalabras claves:Autores:Clements C., Crawford A.D., De Witte P.A.M., Edrada-Ebel R., Esguerra C.V., Gebruers E., Gray A.I., Harvey A.L., María Lorena Cordero-MaldonadoFuentes:rraaescopusDeep learning image recognition enables efficient genome editing in zebrafish by automated injections
ArticleAbstract: One of the most popular techniques in zebrafish research is microinjection. This is a rapid and effiPalabras claves:Autores:Boland R., Crawford A.D., De Sonneville J., Heins-Marroquin U., María Lorena Cordero-Maldonado, Meijer A.H., Perathoner S., Spaink H.P., Van der Kolk K.J.Fuentes:scopusCHD2 variants are a risk factor for photosensitivity in epilepsy
ArticleAbstract: Photosensitivity is a heritable abnormal cortical response to flickering light, manifesting as partiPalabras claves:Eyelid myoclonia with absences, Photosensitive, SeizureAutores:Afrikanova T., Berkovic S.F., Boustred C., Cantonetti L., Capovilla G., Chinthapalli V.K., Coppola A., Covanis A., Crawford A.D., De Kovel C.G.F., Del Gaudio L., Drury S., Esguerra C.V., Galizia E.C., Helbig I., Jacmin M., Jocic-Jakubi B., Koeleman B.P.C., Krause R., Lehesjoki A.E., Lench N., Lerche H., Leu C., María Lorena Cordero-Maldonado, Martins T.G., Mefford H.C., Moller R.S., Muhle H., Mullen S.A., Myers C.T., Nürnberg P., Palotie A., Parisi P., Pendziwiat M., Piccioli M., Ruppert A.K., Sadleir L.G., Sander T., Scheffer I.E., Schneider A.L., Schubert J., Sisodiya S.M., Stephani U., Striano S., Thiele H., Trenité D.G.A.K.N., Veggiotti P.Fuentes:scopusGender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies
ArticleAbstract: Public transcriptomic studies have shown that several genes display pronounced gender differences inPalabras claves:Alzheimer’s disease, Gender differences, Tau, Tauopathies, transcriptomics, zebrafishAutores:Antony P., Buttini M., Crawford A.D., Forster J.I., Garcia P., Glaab E., Köglsberger S., María Lorena Cordero-MaldonadoFuentes:scopusFishing anti-inflammatories from known drugs: In silico repurposing, design, synthesis and biological evaluation of bisacodyl analogues
ArticleAbstract: Herein is described in silico repositioning, design, synthesis, biological evaluation and structure-Palabras claves:Anti-inflammatory assay, Anti-inflammatory database, Atom-based bilinear indices, Bisacodyl, Diarylmethylpyridines, Repurposing, ToMoCoMD-CARDD softwareAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Dumas F., Ferroud C., Giner R.M., Guerra Y.R., Lerari V., Marín M., Siverio-Mota D., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:googlescopusEvaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays
ArticleAbstract: Ethnopharmacological relevance: In South Africa, medicinal plants have a history of traditional use,Palabras claves:Cotyledon orbiculata, Lobostemon fruticosus, Pro-angiogenesis, Scabiosa columbaria, Traditional medicine, Wound healing, zebrafishAutores:Crawford A.D., Hattingh A.C., Katerere D., Koekemoer T.C., María Lorena Cordero-Maldonado, Mhlongo F., Sandasi M., van de Venter M., Viljoen A.M.Fuentes:scopus