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Calpains as a target for therapy of neurodegenerative diseases: Putative role of lithium
ReviewAbstract: Lithium is a simple cation that has been used clinically since 1950 for the treatment of bipolar disPalabras claves:apoptosis, Calcium homeostasis, Calpain, Cell cycle control, Cytoskeleton, DNA damage, Kinases, Lithium, Neurodegeneration, neurodegenerative diseases, signal transduction, Tau kinasesAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Junyent F., Pallás M., Verdaguer E.Fuentes:scopusGene expression profile in JNK3 null mice: A novel specific activation of the PI3K/AKT pathway
ArticleAbstract: JNK3 is mainly expressed in the CNS and it plays a crucial role in neuronal death in several neurodePalabras claves:Akt, Gene profiling, JNK, Neurodegeneration, neuroprotection, PI3KAutores:Antoni Camins, Auladell C., De Lemos M.L., Ferrer I., Folch J., Junyent F., Ortuo-Sahagún D., Pallás M., Romero R., Verdaguer E., Zárate C.B.Fuentes:scopusNeuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms
ArticleAbstract: The activation of c-Jun-N-terminal kinases (JNK) pathway has been largely associated with the pathogPalabras claves:c-Jun N-terminal kinase, Excitotoxicity, hippocampus, inflammation, Kainic acid, Knockout mice, Neurodegeneration, neuroprotectionAutores:Antoni Camins, Auladell C., Castro-Torres R.D., De Lemos M.L., Folch J., Junyent F., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusNeuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)
ArticleAbstract: Dietary interventions have been proposed as a way to increase lifespan and improve health. The senesPalabras claves:ADAM10, ageing, BDNF, Neurodegeneration, NFκB, Sirtuin 1Autores:Antoni Camins, Folch J., Gutiérrez-Cuesta J., Jiménez A., Junyent F., Lau A., Ortuo-Sahagún D., Pallás M., Tajes M., Verdaguer E.Fuentes:scopusLack of Jun-N-terminal kinase 3 (JNK3) does not protect against neurodegeneration induced by 3-nitropropionic acid
ArticleAbstract: Aims: 3-Nitropropionic acid (3-NP) is a toxin that replicates most of the clinical and pathophysioloPalabras claves:Huntington, JNK3, Neurodegeneration, Nitropropionic acidAutores:Antoni Camins, Auladell C., De Lemos M.L., Folch J., Junyent F., Pallás M., Verdaguer E., Zárate C.B.Fuentes:scopusPrevention of epilepsy by taurine treatments in mice experimental model
ArticleAbstract: An experimental model based on kainic acid (KA) injections replicates many phenomenological featuresPalabras claves:Kainic acid, Neurodegeneration, neuroprotectionAutores:Antoni Camins, Auladell C., Duque D., Junyent F., Pallás M., Romero R., Utrera J.Fuentes:scopusSystemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
ArticleAbstract: The intraperitoneal administration of 3-nitropropionic acid, which is commonly used to induce toxiciPalabras claves:apoptosis, Huntington's disease, Neurodegeneration, RAT, Striatum, TUNELAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Junyent F., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopus