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Characterization of the A<inf>2A</inf>R-D<inf>2</inf>R interface: Focus on the role of the C-terminal tail and the transmembrane helices
ArticleAbstract: A single serine point mutation (S374A) in the adenosine A2A receptor (A2AR) C-terminal tail reducesPalabras claves:Adenosine A receptor 2A, Dopamine D receptor 2, G protein coupled receptors, Heteromerization, Protein-protein interaction, Transmembrane segmentsAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Corrales F., Flajolet M., Frankowska M., Fuxe K., Gómez-Soler M., Heintz N., Marcellino D., Narváez M., Tarakanov A.O., W. Romero-FernandezFuentes:scopusGPCR heteromers and their allosteric receptor-receptor interactions
ArticleAbstract: The concept of intramembrane receptor-receptor interactions and evidence for their existences were iPalabras claves:Adenosine receptor, allosteric modulation, Dopamine receptors, GPCR, moonlighting, Oligomers, Receptor G protein coupling, Receptor interface, Receptor mosaic, Receptor recognition, Receptor signaling, Receptor trafficking, Triplet homologiesAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Ferraro L., Filip M., Frankowska M., Fuxe K., Guidolin D., Marcellino D., Tanganelli S., Tarakanov A.O., W. Romero-Fernandez, Woods A.S.Fuentes:scopusDissecting the conserved NPxxY motif of the M <inf>3</inf> muscarinic acetylcholine receptor: Critical role of Asp-7.49 for receptor signaling and multiprotein complex formation
ArticleAbstract: Acetylcholine challenge produces M 3 muscarinic acetylcholine receptor activation and accessory/scafPalabras claves:Desensitization, G protein-coupled receptors, Monomeric small G proteins, Muscarinic acetylcholine receptors, NPxxY motif, Phospholipase C, Phospholipase DAutores:Borroto-Escuela D.O., Ciruela F., Correia P.A., Fuxe K., García-Negredo G., Garriga P., W. Romero-FernandezFuentes:scopusDiversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
ReviewAbstract: Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecularPalabras claves:allosteric modulation, Biased recognition, Biased signaling, G protein-coupled receptor, Heterodimerization, Receptor diversity, Receptor heterodimers, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Díaz-Cabiale Z., Ferraro L., Filip M., Fuxe K., Garriga P., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions
ArticleAbstract: Dopamine D2 and D4 receptors partially codistribute in the dorsal striatum and appear to play a fundPalabras claves:allosteric modulation, Dopamine D R receptor 2, Dopamine D R receptor 4, G protein-coupled receptors, Heteromerization, Protein-protein interactions.Autores:Agnati L.F., Borroto-Escuela D.O., Craenenbroeck K.V., Fuxe K., Guidolin D., Haegeman G., Rivera A., Tarakanov A.O., W. Romero-Fernandez, Woods A.S.Fuentes:scopusDopamine D<inf>4</inf> receptor oligomerization - Contribution to receptor biogenesis
ArticleAbstract: Dopamine D4 receptors (D4Rs) are G protein-coupled receptors that play a role in attention and cogniPalabras claves:bioluminescence resonance energy transfer, dimerization, dopamine D receptor 4, G protein-coupled receptors, receptor biogenesisAutores:Borroto-Escuela D.O., Ciruela F., Fuxe K., Haegeman G., Lintermans B., Rondou P., Skieterska K., Van Craenenbroeck K., Vanhoenacker P., W. Romero-FernandezFuentes:scopusMoonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field
ReviewAbstract: There is serious interest in understanding the dynamics of the receptor-receptor and receptor-proteiPalabras claves:G protein-coupled receptors, Heterodimerization, moonlighting, neuropsychiatric disorders, neurotherapeutic targets, receptorreceptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Fuxe K., Palkovits M., Tarakanov A.O., W. Romero-FernandezFuentes:scopusMuscarinic receptor family interacting proteins: Role in receptor function
ArticleAbstract: G protein-coupled receptors constitute one of the most important families of membrane receptors throPalabras claves:G protein coupled receptors, Interacting proteins, Muscarinic receptors, Signal network, tandem affinity purificationAutores:Borroto-Escuela D.O., Ciruela F., Correia P.A., Fuxe K., Garriga P., Narváez M., W. Romero-FernandezFuentes:scopusOn the existence of a possible A<inf>2A</inf>-D<inf>2</inf>-β- arrestin2 complex: A<inf>2A</inf> agonist modulation of D<inf>2</inf> agonist-induced β-arrestin2 recruitment
ArticleAbstract: Given that coactivation of adenosine A2A (A2AR) and dopamine D2 (D2R) receptors results in the coaggPalabras claves:allosteric modulation, G-protein-coupled receptors, Heteromerization, Internalization, receptor-protein interactionAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Fuxe K., Tarakanov A.O., W. Romero-FernandezFuentes:scopus