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2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents
ArticleAbstract: Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synPalabras claves:Autores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusExploring the orthogonal chemoselectivity of 2,4,6-trichloro-1,3,5-triazine (TCT) as a trifunctional linker with different nucleophiles: Rules of the game
ArticleAbstract: The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyPalabras claves:density functional theory, Electrostatic potential maps, NBO calculations, S-triazine, Triorthogonal linkerAutores:Alberício F., B. G. De la Torre, El-Faham A., Sharma A.Fuentes:scopusPerfluorophenyl derivatives as unsymmetrical linkers for solid phase conjugation
ArticleAbstract: Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two diffPalabras claves:Chimera, conjugation, Fluorolinkers, Peptide stapling, Solid-phase peptide synthesisAutores:Alapour S., Alberício F., B. G. De la Torre, Koorbanally N.A., Ramjugernath D., Sharma A.Fuentes:scopusPhenol as a modulator in the chemical reactivity of 2,4,6-Trichloro-1,3,5-triazine: Rules of the Game II
ArticleAbstract: 2,4,6-Trichloro-1,3,5-triazine (TCT) is a privileged core that has the capacity to undergo sequentiaPalabras claves:Autores:Alberício F., B. G. De la Torre, El-Faham A., Sharma A., Sheyi R.Fuentes:scopusInvestigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core
ArticleAbstract: An example of triorthogonal chemoselectivity is reported here for the first time. In this regard, aPalabras claves:Autores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A., Sheyi R.Fuentes:scopusUnderstanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives
ArticleAbstract: An in silico study, using the GALAS algorithm available in ACD/PhysChem Suite, was performed to calcPalabras claves:Autores:Alberício F., B. G. De la Torre, El-Faham A., Manne S.R., Sazonovas A., Sharma A.Fuentes:scopus