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Breaking a Couple: Disulfide Reducing Agents
ReviewAbstract: Cysteine is present in a large number of natural and synthetic (bio)molecules. Although the thiol siPalabras claves:Cysteine, cystine, Disulfide bridges, reducing agents, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, Mthembu S.N., Sharma A.Fuentes:scopusExploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups
ArticleAbstract: In the field of bioconjugation, linker development has witnessed massive growth in recent years. 2,4Palabras claves:Bioconjuation, Linker, Orthogonal chemoselectivity, Orthogonality, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Kumar A., Sharma A.Fuentes:scopusN-methylation in amino acids and peptides: Scope and limitations
ReviewAbstract: Active pharmaceutical ingbkp_redients (APIs) can be divided into two types, namely chemical and biolPalabras claves:cyclic peptides, NMAA, side-reactions, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A., Monaim S.A.H.A., Sharma A.Fuentes:scopusOctagel resin-a new peg-ps-based solid support for solid-phase peptide synthesis
OtherAbstract: OctaGel resin is a unique, highly uniformed surface-active resin. Here, we compared the performancePalabras claves:ACP-decapeptide, Chem matrix, OctaGel resin, polystyrene resin, Sem, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, Jad Y.E., Ramkisson S., Sharma A.Fuentes:scopusPerfluorophenyl derivatives as unsymmetrical linkers for solid phase conjugation
ArticleAbstract: Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two diffPalabras claves:Chimera, conjugation, Fluorolinkers, Peptide stapling, Solid-phase peptide synthesisAutores:Alapour S., Alberício F., B. G. De la Torre, Koorbanally N.A., Ramjugernath D., Sharma A.Fuentes:scopusTetrahydropyranyl: A Non-aromatic, Mild-Acid-Labile Group for Hydroxyl Protection in Solid-Phase Peptide Synthesis
ArticleAbstract: The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side-chain hPalabras claves:Protecting groups, serine, Solid-phase peptide synthesis, tetrahydropyranyl group, threonineAutores:Alberício F., B. G. De la Torre, El-Faham A., Hortensia Rodriguez Cabrera, Ramos-Tomillero I., Sharma A.Fuentes:scopus