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Anti-aging properties of melatonin in an in vitro murine senescence model: Involvement of the sirtuin 1 pathway
ArticleAbstract: Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerabPalabras claves:ADAM10, aging, Neurodegeneration, NFκB, Oxidative Stress, P53Autores:Antoni Camins, Gutiérrez-Cuesta J., Ortuo-Sahagún D., Pallás M., Tajes M.Fuentes:scopusActivation of Akt by lithium: Pro-survival pathways in aging
ArticleAbstract: The effects of lithium on senescence were investigated using the senescence-accelerated mouse pronePalabras claves:aging, Lithium chloride, Neurodegeneration, neuroprotection, SAMP8Autores:Antoni Camins, Casadesús G., Chou S.P., Pallás M., Smith M.A., Tajes M., Yeste-Velasco M., Zhu X.Fuentes:scopusEffects of melatonin in the brain of the senescence-accelerated mice-prone 8 (SAMP8) model
ArticleAbstract: Summary. Senescence-accelerated mice (SAM) represent an aging model establish by selective inbreedinPalabras claves:CDK5, GSK3beta, melatonin, TauAutores:Antoni Camins, Gutiérrez-Cuesta J., Jiménez A., Pallás M., Tajes M.Fuentes:scopusEvaluation of acute antiapoptotic effects of Li<sup>+</sup> in neuronal cell cultures
ArticleAbstract: Li+ exerts protective effect against several neurotoxins in neuronal cell preparations. Here we examPalabras claves:Autores:Alvira D., Antoni Camins, Folch J., Pallás M., Rimbau V., Tajes M., Verdaguer E., Yeste M.Fuentes:scopusEvaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
ArticleAbstract: We examined the effect of melatonin on pro-survival processes in three groups of mice. Untreated senPalabras claves:aging, Amyloid β, BRAIN, Cysteine proteases, Sirt1Autores:Antoni Camins, Coto-Montes A., Gutiérrez-Cuesta J., Jiménez A., Pallás M., Tajes M.Fuentes:scopusEvaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells
ArticleAbstract: Caspase-3 is a key protein involved in the classical apoptosis mechanism in neurons, as in many othePalabras claves:Acute toxicity, apoptosis, Caspase-3, Cell-cycle, Cerebellar granule neurons, Oxidative StressAutores:Alvira D., Antoni Camins, Folch J., Forsby A., López-Querol M., Pallás M., Rimbau V., Sureda F.X., Tajes M.Fuentes:scopusInhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons
ArticleAbstract: The biochemical pathways involved in neuronal cell death in Parkinson's disease are not completely cPalabras claves:apoptosis, Cerebellar granule cells, Cyclin dependent kinases, flavopiridol, Vitamin EAutores:Allgaier C., Alvira D., Antoni Camins, de Arriba S.G., Jiménez A., Matute C., Pallás M., Tajes M., Trullàs R., Verdaguer E.Fuentes:scopusInhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease
ArticleAbstract: In this study, the effects of melatonin on MPP+-treated cerebellar granule neurons (CGNs) in culturePalabras claves:apoptosis, Calpain, caspase, CDK5, Cerebellar granule cells, MPP +Autores:Acuña-Castroviejo D., Alvira D., Antoni Camins, Folch J., Pallás M., Tajes M., Verdaguer E.Fuentes:scopusModulation of SIRT1 expression in different neurodegenerative models and human pathologies
ArticleAbstract: We examined the expression of SIRT1 in several experimental paradigms of human pathologies. We usedPalabras claves:3-nitropropionic acid, BRAIN, cell cycle, kainate, MPP+, rotenoneAutores:Alvira D., Antoni Camins, Canudas A.M., Crespo-Biel N., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Pizarro J.G., Sureda F.X., Tajes M., Yeste-Velasco M.Fuentes:scopusModulation of sirtuins: New targets for antiageing
ReviewAbstract: Aging is characterized by a progressive deterioration of physiological functions and metabolic procePalabras claves:ageing, Deacetylases, neurodegenerative diseases, PolyphenolsAutores:Antoni Camins, Gutiérrez-Cuesta J., Pallás M., Tajes M., Verdaguer E.Fuentes:scopus