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CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo
ArticleAbstract: Protein Kinase CK2 is a serine-threonine kinase frequently deregulated in many human tumors. Here, wPalabras claves:apoptosis, Cancer targeted therapy, Casein kinase 2Autores:Acevedo B.E., Alonso D.F., Ariosa J., Bacardí D.M., Baladron I., Besada-Pérez V., Betancourt L., Castellanos L.R., Cosme K., Cruz M., Díaz A., Falcón-Cama V., Farina H., Garay H.E., Gil J., Gómez D., Gómez R., González L.J., Hernández I., Herrera L., López C., López-Mola E., López-Saura P.A., Marcelo J.L., Mendoza O., Perea-Rodríguez S.E., Perera Y., Puchades Y., Reyes O., Rodriguez A., Sánchez A., Santana A., Serrano J.M., Sigman H., Silva R., Solares M., Thelvia I. Ramos Gómez, Valenzuela-Silva C.M.Fuentes:googlescopusAdjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: A randomized, double-blind, placebo-controlled study
ArticleAbstract: Background: High antibiotic resistance is described in atypical Mycobacteriosis, mainly by MycobactePalabras claves:Autores:Bello-Rivero I., Fernández-Olivera N., García-García I., González-Méndez L., Jiménez-Madrigal G., López-Saura P.A., Martínez-Sánchez G., Milanés-Virelles M.T., Rodríguez-Acosta C., Sánchez-de la Osa R.B., Santos-Herrera Y., Thelvia I. Ramos Gómez, Valdés-Quintana M., Valenzuela-Silva C.M.Fuentes:googlescopusForms and methods for interferon’s encapsulation
ReviewAbstract: Interferons (IFNs) are cytokines involved in the immune response that act on innate and adaptive immPalabras claves:Antiproliferative, antiviral, Drug delivery system, Encapsulate IFNs, formulation, IFN-α, IFN-β, IFN-γ, Immunomodulator, interferons, Liposomes, Microparticles, Nanoparticles, Pegylation, Polymeric micellesAutores:Leandro Santiago Padilla, Parra N.C., Santana S.P., Santiago Nelson Vispo, Thelvia I. Ramos Gómez, Toledo Alonso J.R., Villacis-Aguirre C.A.Fuentes:googlescopusSafety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies
ArticleAbstract: Background: Cervical cancer is now considered the second leading cause of death among women worldwidPalabras claves:Autores:Acevedo B.E., Alonso D.F., Baladron I., Castillo D., Díaz A., Gómez R., González C.A., Herrera L., López-Saura P.A., Perea-Rodríguez S.E., Santana A., Sigman H., Solares A.M., Thelvia I. Ramos Gómez, Valenzuela-Silva C.M.Fuentes:googlescopusVariable level expression of hepatitis C virus core protein in a prokaryotic system. Analysis of the humoral response against it in rabbits
ArticleAbstract: Experimental evidence suggests that the hepatitis C virus (HCV) core protein has several biologicalPalabras claves:E. coli, expression, HCV, Hepatitis C virus, Immunogenicity, Nucleocapsid core protein, purificationAutores:Acosta-Rivero N., Dueñas-Carrera S., Garcia C., Guerra I., Lorenzo L.J., Morales J., Pena M., Thelvia I. Ramos GómezFuentes:googlescopusRecombinant gamma interferon for the treatment of pulmonary and mycobacterial diseases
ArticleAbstract: An increased antibiotic resistance is described for Mycobacterium tuberculosis and atypical mycobactPalabras claves:BCG, Idiopathic pulmonary fibrosis, Interferon gamma, Lymphadenitis, Multidrug-resistant pulmonary tuberculosis, Mycobacteria, Mycobacterium avium complexAutores:Abreu G., Cayón I., García I., González-Méndez L., Jiménez G., López P., Milanés M.T., Sánchez R.B., Santos Y., Thelvia I. Ramos Gómez, Valdés M., Valenzuela-Silva C.M.Fuentes:googlescopusPresence of the G1138A mutation in the FGFR3 coding gene in a group of Cuban achondroplasia patients
ArticleAbstract: Achondroplasia, inherited as an autosomal dominant trait, is the most common human skeletal dysplasiPalabras claves:Achondroplasia, Autosomal dominant, FGFR3, Hipoachondroplasia, Osteochondrodysplasias, Thanatophoric dysplasiaAutores:Avella A.B., Baute L.H., Fernandez S.O., Mesa T.C., Peralta E.M., Thelvia I. Ramos GómezFuentes:googlescopus