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Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis
ArticleAbstract: Familial Alzheimer's disease (FAD) is characterized by autosomal dominant heritability and early disPalabras claves:Autores:Barrera-Ocampo A., De Zeeuw C.I., Ferrer I., Glatzel M., Hagel C., Korwitz A., Langer T., Lopera F., María Fernanda Vinueza-Veloz, Rodríguez-Labrada R., Schonewille M., Sepulveda-Falla D., Velazquez-Perez L., Villegas A., Zhou H., Zhou K.Fuentes:scopusReducing GBA2 activity ameliorates neuropathology in niemann-pick type C mice
ArticleAbstract: The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly reduPalabras claves:Autores:Aerts J.M.F.G., Aten J., Boot R.G., Claessen N., De Zeeuw C.I., Lin Z., María Fernanda Vinueza-Veloz, Marques A.R.A., Mirzaian M., Moro D.H., Ottenhoff R., Overkleeft H.S., Van Roomen C.P.A.A., Yildiz Y., Zhou K.Fuentes:scopusReevaluating the Role of LTD in Cerebellar Motor Learning
ArticleAbstract: Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be rePalabras claves:Autores:Amerika W., Boele H., De Jeu M., De Zeeuw C.I., Gao Z., Hoebeek F.E., Huganir R., Linden D., María Fernanda Vinueza-Veloz, Schonewille M., Šimek A., Steinberg J., Takamiya K.Fuentes:scopusThe effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice
ArticleAbstract: Fragile X syndrome (FXS) is the most common inherited form of intellectual disability. Patients withPalabras claves:Avoidance behavior, Cue recognition, Erasmus Ladder, Fmr1 KO, fragile X syndrome, locomotion, MGluR5 inhibitor, Motor learning, Procedural memory formationAutores:Bosman L.W.J., Buijsen R.A.M., Cupido A., De Zeeuw C.I., Koekkoek S.K.E., María Fernanda Vinueza-Veloz, Oostra B.A., Potters J.W., Willemsen R.Fuentes:scopus