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Biological significance of the thermodynamic stability of crispr structures associated with unconventional functions
ArticleAbstract: The clustered regularly interspaced short palindromic repeats (CRISPR) are genetic sequences that coPalabras claves:CRISPR, MFE, transcriptionAutores:Alvarado Y.J., Fernández-Materán F.V., González-Paz L.A., Joan Vera-Villalobos, José Luis Paz, Lossada C.A., Luis S. Moncayo, Parra M.M., Pérez A.E., Portillo E., Romero F.Fuentes:scopusA bioinformatics study of structural perturbation of 3CL-protease and the HR2-domain of SARS-CoV-2 induced by synergistic interaction with ivermectins
ArticleAbstract: The pandemic caused by SARS-CoV-2 forces drug research to combat it. Ivermectin, an FDA approved antPalabras claves:covid-19, Ivermectin, Molecular docking, molecular dynamics, SARS-COV-2Autores:Alvarado Y.J., González-Paz L.A., Joan R. Vera V., Joan Vera-Villalobos, José Luis Paz, Lossada C.A., Luis S. Moncayo, Pérez A.E., Portillo E., Romero F., San-Blas E.Fuentes:googlescopusInteraction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT
ArticleAbstract: The COVID-19 pandemic has accelerated the study of drugs, most notably ivermectin and more recentlyPalabras claves:ANM, covid-19, GNM, Volume fluctuation, Volume Molar, VoronoiAutores:Alvarado Y.J., Fernando Javier Torres, González-Paz L.A., Hurtado-León M.L., Jeffreys L.N., Joan Vera-Villalobos, José Luis Paz, Loroño M.A., Lossada C.A., Olivarez Y., Vera E., Vivas A.Fuentes:scopusThermodynamics and Conformational Dynamics of Primer Nucleotide Sequences Associated with Monkeypox Virus (MpxV): Comparative Analysis of Stability and Specificity with a Biophysical-Computational Approach
ArticleAbstract: COVID-19 pandemic has shown the need to detect new pathogens quickly. Currently, attention has beenPalabras claves:molecular dynamics, OPG, orthopoxviruses, primers, SWAXS curveAutores:Alvarado Y.J., David Santiago Coll, González-Paz L.A., Hurtado-León M.L., Jeffreys L.N., Joan Vera-Villalobos, José Luis Paz, Lossada C.A., Yovani Marrero-PonceFuentes:googlescopus