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A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
ArticleAbstract: In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug toPalabras claves:antibody-ACE2 fusion, Biparatopic, covid-19, neutralizing antibody, SARS-COV-2Autores:Chen C., Chen L., Fu W., Gao W., Huang X., James W.S., Javier Gilbert Jaramillo, Jiang W., Knight M.L., Lee S.M.Y., Liu X., Luo Y., Miao X., Pang T., Rijal P., Song X., Sun J., Tan T.K., Tang Y., Townsend A.R., Tsun A., Wan L., Wang C., Wu F., Xu Y., Yan Y., Yuan Z., Zou Y.Fuentes:scopusAuthor Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 (Nature Structural & Molecular Biology, (2020), 27, 9, (846-854), 10.1038/s41594-020-0469-6)
OtherAbstract: In the version of this article initially published, author Jiandong Huo’s name was spelt incorrectlyPalabras claves:Autores:Bas A.L., Buttigieg K.R., Carrique L., Carroll M.W., Clare D.K., Coombes N., Dumoux M., Duyvesteyn H.M.E., Elmore M.J., Harrison P.J., Huo J., James W.S., Javier Gilbert Jaramillo, Knight M.L., Malinauskas T., Mikolajek H., Moynié L., Naismith J.H., Owens R.J., Radecke J., Ren J., Rijal P., Ruza R.R., Shah P.N.M., Stuart D.I., Tan T.K., Townsend A.R., Tree J.A., Vogirala V.K., Ward P.N., Weckener M., Zhao Y., Zhou D.Fuentes:scopusBreadth and function of antibody response to acute SARS-CoV-2 infection in humans
ArticleAbstract: Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) havePalabras claves:Autores:Chen C.P., Chen T.H., Cheng C.Y., Cheng S.H., Daniels R.S., Harding A.C., Harvey R., Huang C.G., Huang K.Y.A., Huang Y.C., Hussain S., James W.S., Jan J.T., Javier Gilbert Jaramillo, Knight M.L., Lin T.Y., Lin Y.C., Liu X., Ma C., McCauley J.W., Rijal P., Schimanski L., Shih S.R., Tan T.K., Townsend A.R.Fuentes:scopusBroadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents
ArticleAbstract: Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on humaPalabras claves:aptamer, covid-19, modified DNA, MT: Oligonucleotides, SARS-COV-2, SELEX, Therapies and Applications, variants of concern, viral neutralizationAutores:Chadwick J., Chase C.N., Gelinas A.D., Harding A.C., James W.S., Janjic N., Javier Gilbert Jaramillo, Lee T., Liu S., Otis M.R., Ream B.E., Schneider D.J., Tan T.K., Zhang C.Fuentes:scopusDivergent trajectories of antiviral memory after SARS-CoV-2 infection
ArticleAbstract: The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection aPalabras claves:Autores:Abuelgasim H., Adland E., Alexander F., Alhussni A., Ali M., Allott K., Arancibia-Cárcamo C.V., Azim Ansari M., Belij-Rammerstorfer S., Bibi S., Blackwell L., Borak M., Brown A., Brown H., Cassar M.P., Cavell B., Clutterbuck E.A., Conlon C.P., Cutteridge J., de Silva T.I., Deeks A.S., Denly L., Dimitriadis S., Dong T., Duncan C.J.A., Eyre D.W., Fassih S., Flaxman A., Foord T., Fordwoh T., Frater J., Fries A., Goulder P., Grist J., Hackstein C.P., Halkerston R., Harding A.C., Hill J., Ho L.P., Holmes J., Horsington B., James T., Javier Gilbert Jaramillo, Jay C., Jeffery K., Johnson S.A., Kerneis S., Kim D., Knight J.C., Kronsteiner B., Lambe T., Lie Y., Lillie K., Linder A., Longet S., Lumley S.F., Marinou S., Matthews P.C., Mellors J., Mentzer A.J., Moore S.C., Morrow J., Neubauer S., Ogbe A., O’Connor D., O’Donnell D., Pace M., Payne R.P., Peng Y., Petousi N., Petropoulos C., Pollard A.J., Raman B., Richter A., Ritter T.G., Rongkard P., Rowland-Jones S.L., Sedik C., Silva-Reyes L., Simmons B., Skelly D.T., Smith H., Stafford L., Stockdale L., Talbot N.P., Taylor A., Taylor S., Thomas S., Thomas S.R., Tipoe T., Tomic A., Travis S., Turtle L., Vieira V.A., Warren Y., Watson A.J.R., Weeks E., Wilson R., Wrin T., Young R.Fuentes:scopusInclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity
ArticleAbstract: Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMPPalabras claves:cGAMP, Influenza a virus, SARS-COV-2, type I interferon, viral vaccine vectorAutores:Beveridge R., Borrow P., Bridgeman A., Chauveau L., Drakesmith H., Frost J.N., Javier Gilbert Jaramillo, Knight M.L., Liu X., Partridge T., Pedroza-Pacheco I., Rehwinkel J., Rijal P., Russell R.A., Tan T.K., Townsend A.R.Fuentes:scopusErratum: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans (PLoS Pathog (2021) 17:2 (e1009352) DOI: 10.1371/journal.ppat.1009352)
OtherAbstract: There is an error in the caption for S2 Fig.The cells in this experiment were transduced to expressPalabras claves:Autores:Chen C.P., Chen T.H., Cheng C.Y., Cheng S.H., Daniels R.S., Harding A.C., Harvey R., Huang C.G., Huang K.Y.A., Huang Y.C., Hussain S., James W.S., Jan J.T., Javier Gilbert Jaramillo, Knight M.L., Lin T.Y., Lin Y.C., Liu X., Ma C., McCauley J.W., Rijal P., Schimanski L., Shih S.R., Tan T.K., Townsend A.R.Fuentes:scopusIntranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice
ArticleAbstract: The SARS-CoV-2 pandemic continues despite the presence of effective vaccines, and novel vaccine apprPalabras claves:Adaptive immunity, covid-19, Mucosal adjuvant, RBD, SARS-COV-2, spike, VaccineAutores:Deimel L.P., James W.S., Javier Gilbert Jaramillo, Liu S., Liu X., Sattentau Q.J.Fuentes:scopusImmunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
ArticleAbstract: Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in thePalabras claves:antibody, B cell, BNT162b2, covid-19, dosing interval, Neutralization, SARS-COV-2, T cell, Vaccine, variants of concernAutores:Abuelgasim H., Adele S., Adland E., Adlou S., Akther H.D., Al-Taei S., Alhussni A., Ali M., Altmann T., Amini A., Angyal A., Arancibia-Cárcamo C.V., Austin J.A., Azim Ansari M., Barnes E., Bayley M., Bridges-Webb A., Brown A., Brown H., Brown R., Carroll M.W., Chalk J., Chand M., Chawla A., Chinnakannan S., Conlon C.P., Cross A., Cutteridge J., de Lara C., de Silva T.I., Deeks A.S., Dejnirattisai W., Denly L., Diffey B., Dimitriadis S., Dobson S.L., Dold C., Donnison T., Drake T.M., Dunachie S.J., Duncan C.J.A., Dupont M., Eyre D.W., Fairman A., Faustini S., Foulkes S., Frater J., Gardiner S., Gillson N., Goulder P., Hackstein C.P., Hall V., Hambleton S., Haniffa M., Hargreaves A., Haworth J., Hering L.M., Holmes J., Hopkins S., Horner E., Hornsby H., Jämsén A., Javier Gilbert Jaramillo, Jeffery K., Johnson S.A., Jones C., Kasanyinga M., Kelly S., Kilby J.A., Kirk R., Klenerman P., Knight M.L., Lawrie A., Lee L., Linder A., Longet S., Malone T., Matthews P.C., Meardon N., Mongkolsapaya J., Moore S.C., Nicols A.R., Payne R.P., Phillips E., Pollard A.J., Reyes L.S., Richter A., Rowland-Jones S.L., Saei A., Sandhar G., Screaton G.R., Shields A., Skelly D.T., Stafford L., Supasa P., Tipton T., Turtle L., Tyerman J.K., Whitham R., Wootton D.G.Fuentes:scopusNeutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago
ArticleAbstract: Combinatorial antibody libraries not only effectively reduce antibody discovery to a numbers game, bPalabras claves:Autores:Dwek R.A., Harding A.C., Huang X., James W.S., Javier Gilbert Jaramillo, Ji Q., Lee C.C.D., Lerner R.A., Li T., Li Y., Li Z., Liu H., Liu L., Ma P., Min C., Qiang M., Saxena A., Shi X., Tao P., Wang F., Wang H., Wang X., Wilson I.A., Wu N.C., Yang G., Yuan M., Zhang C., Zhang Y., Zhu X.Fuentes:scopus