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G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
ArticleAbstract: Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal demenPalabras claves:amyotrophic lateral sclerosis, C9orf72, frontotemporal dementia, G-quadruplexAutores:Abdelkarim S., Balendra R., Boykin D.W., Calvo A., Chio A., Clarke M., Clayton E.L., Farahat A.A., Fratta P., Heslegrave A., Houlden H., Isaacs A.M., Ismail M.A., Javier Gilbert Jaramillo, Konrad M.T., Mitchell J.S., Moens T.G., Neidle S., Niccoli T., Nicoll A.J., Parkinson G., Partridge L., Patani R., Polke J.M., Preza E., Simone R., Stephens C.E., Vo T., Wilson K.M., Wilson W.D., Woodling N.S., Wray S., Zetterberg H.Fuentes:scopusKetotherapeutics for neurodegenerative diseases
Book PartAbstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are, respectively, the most prevalent and fastPalabras claves:Alzheimer's disease, D-β-hydroxybutyrate, inflammation, Insulin, Ketone bodies, Ketone ester, Microglia, Mitochondria, Oxidative Stress, Parkinson's DiseaseAutores:Clarke K., Javier Gilbert Jaramillo, Norwitz N.G., Soto A.Fuentes:scopusThe potential contribution of impaired brain glucose metabolism to congenital Zika syndrome
ReviewAbstract: The Zika virus (ZIKV) became a major worldwide public concern in 2015 due to the congenital syndromePalabras claves:congenital Zika syndrome, diet, glucose, Ketone bodies, metabolism, microcephaly, Zika VirusAutores:Clarke K., Garcez P., James W.S., Javier Gilbert Jaramillo, Molnár Z.Fuentes:scopus