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Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents
ArticleAbstract: Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on humaPalabras claves:aptamer, covid-19, modified DNA, MT: Oligonucleotides, SARS-COV-2, SELEX, Therapies and Applications, variants of concern, viral neutralizationAutores:Chadwick J., Chase C.N., Gelinas A.D., Harding A.C., James W.S., Janjic N., Javier Gilbert Jaramillo, Lee T., Liu S., Otis M.R., Ream B.E., Schneider D.J., Tan T.K., Zhang C.Fuentes:scopusA novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
ArticleAbstract: In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug toPalabras claves:antibody-ACE2 fusion, Biparatopic, covid-19, neutralizing antibody, SARS-COV-2Autores:Chen C., Chen L., Fu W., Gao W., Huang X., James W.S., Javier Gilbert Jaramillo, Jiang W., Knight M.L., Lee S.M.Y., Liu X., Luo Y., Miao X., Pang T., Rijal P., Song X., Sun J., Tan T.K., Tang Y., Townsend A.R., Tsun A., Wan L., Wang C., Wu F., Xu Y., Yan Y., Yuan Z., Zou Y.Fuentes:scopusInclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity
ArticleAbstract: Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMPPalabras claves:cGAMP, Influenza a virus, SARS-COV-2, type I interferon, viral vaccine vectorAutores:Beveridge R., Borrow P., Bridgeman A., Chauveau L., Drakesmith H., Frost J.N., Javier Gilbert Jaramillo, Knight M.L., Liu X., Partridge T., Pedroza-Pacheco I., Rehwinkel J., Rijal P., Russell R.A., Tan T.K., Townsend A.R.Fuentes:scopusIntranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice
ArticleAbstract: The SARS-CoV-2 pandemic continues despite the presence of effective vaccines, and novel vaccine apprPalabras claves:Adaptive immunity, covid-19, Mucosal adjuvant, RBD, SARS-COV-2, spike, VaccineAutores:Deimel L.P., James W.S., Javier Gilbert Jaramillo, Liu S., Liu X., Sattentau Q.J.Fuentes:scopusImmunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
ArticleAbstract: Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in thePalabras claves:antibody, B cell, BNT162b2, covid-19, dosing interval, Neutralization, SARS-COV-2, T cell, Vaccine, variants of concernAutores:Abuelgasim H., Adele S., Adland E., Adlou S., Akther H.D., Al-Taei S., Alhussni A., Ali M., Altmann T., Amini A., Angyal A., Arancibia-Cárcamo C.V., Austin J.A., Azim Ansari M., Barnes E., Bayley M., Bridges-Webb A., Brown A., Brown H., Brown R., Carroll M.W., Chalk J., Chand M., Chawla A., Chinnakannan S., Conlon C.P., Cross A., Cutteridge J., de Lara C., de Silva T.I., Deeks A.S., Dejnirattisai W., Denly L., Diffey B., Dimitriadis S., Dobson S.L., Dold C., Donnison T., Drake T.M., Dunachie S.J., Duncan C.J.A., Dupont M., Eyre D.W., Fairman A., Faustini S., Foulkes S., Frater J., Gardiner S., Gillson N., Goulder P., Hackstein C.P., Hall V., Hambleton S., Haniffa M., Hargreaves A., Haworth J., Hering L.M., Holmes J., Hopkins S., Horner E., Hornsby H., Jämsén A., Javier Gilbert Jaramillo, Jeffery K., Johnson S.A., Jones C., Kasanyinga M., Kelly S., Kilby J.A., Kirk R., Klenerman P., Knight M.L., Lawrie A., Lee L., Linder A., Longet S., Malone T., Matthews P.C., Meardon N., Mongkolsapaya J., Moore S.C., Nicols A.R., Payne R.P., Phillips E., Pollard A.J., Reyes L.S., Richter A., Rowland-Jones S.L., Saei A., Sandhar G., Screaton G.R., Shields A., Skelly D.T., Stafford L., Supasa P., Tipton T., Turtle L., Tyerman J.K., Whitham R., Wootton D.G.Fuentes:scopusSARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
ArticleAbstract: Background: Laboratory diagnosis of SARS-CoV-2 infection (the cause of COVID-19) uses PCR to detectPalabras claves:Biomarker, Blood, covid-19, Laboratory safety, RNA, SARS-COV-2, Viraemia, Viral loadAutores:Andersson M.I., Arancibia-Cárcamo C.V., Auckland K., Baillie J.K., Barnes E., Beneke T., Bibi S., Brooks T.J.G., Carroll M.W., Crook D.W., Dingle K., Dold C., Downs L.O., Dunn L., Eyre D.W., Harvala H., Hoosdally S., Ijaz S., James T., James W.S., Javier Gilbert Jaramillo, Jeffery K., Justice A., Klenerman P., Knight J.C., Knight M.L., Liu X., Lumley S.F., Matthews P.C., McNaughton A.L., Mentzer A.J., Mongkolsapaya J., Oakley S., Oliveira M.S., Peto T., Ploeg R.J., Ratcliff J., Robbins M.J., Roberts D.J., Rudkin J., Russell R.A., Screaton G.R., Semple M.G., Simmonds P., Skelly D.T., Stoesser N., Turtle L., Wareing S., Zambon M.Fuentes:scopusStructures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2
ArticleAbstract: Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has bePalabras claves:Antibody cocktail, Antibody-antigen complex, Human monoclonal antibody, In vitro and in vivo function, Receptor-binding domain epitope, SARS-COV-2Autores:Buttigieg K.R., Carroll M.W., Charlton S., Chen C., Chen C.P., Chen X., Cheng S.H., Donat R.F., Duyvesteyn H.M.E., Fry E.E., Ginn H.M., Harding A.C., Huang K.Y.A., James W.S., Javier Gilbert Jaramillo, Lien C.E., Lin M.Y., Lin T.Y., Ma C., Qin L., Ren J., Rijal P., Schimanski L., Stuart D.I., Tan T.K., Townsend A.R., Tree J.A., Zhao Y., Zhou D.Fuentes:scopus