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A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
ArticleAbstract: In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug toPalabras claves:antibody-ACE2 fusion, Biparatopic, covid-19, neutralizing antibody, SARS-COV-2Autores:Chen C., Chen L., Fu W., Gao W., Huang X., James W.S., Javier Gilbert Jaramillo, Jiang W., Knight M.L., Lee S.M.Y., Liu X., Luo Y., Miao X., Pang T., Rijal P., Song X., Sun J., Tan T.K., Tang Y., Townsend A.R., Tsun A., Wan L., Wang C., Wu F., Xu Y., Yan Y., Yuan Z., Zou Y.Fuentes:scopusAuthor Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 (Nature Structural & Molecular Biology, (2020), 27, 9, (846-854), 10.1038/s41594-020-0469-6)
OtherAbstract: In the version of this article initially published, author Jiandong Huo’s name was spelt incorrectlyPalabras claves:Autores:Bas A.L., Buttigieg K.R., Carrique L., Carroll M.W., Clare D.K., Coombes N., Dumoux M., Duyvesteyn H.M.E., Elmore M.J., Harrison P.J., Huo J., James W.S., Javier Gilbert Jaramillo, Knight M.L., Malinauskas T., Mikolajek H., Moynié L., Naismith J.H., Owens R.J., Radecke J., Ren J., Rijal P., Ruza R.R., Shah P.N.M., Stuart D.I., Tan T.K., Townsend A.R., Tree J.A., Vogirala V.K., Ward P.N., Weckener M., Zhao Y., Zhou D.Fuentes:scopusBreadth and function of antibody response to acute SARS-CoV-2 infection in humans
ArticleAbstract: Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) havePalabras claves:Autores:Chen C.P., Chen T.H., Cheng C.Y., Cheng S.H., Daniels R.S., Harding A.C., Harvey R., Huang C.G., Huang K.Y.A., Huang Y.C., Hussain S., James W.S., Jan J.T., Javier Gilbert Jaramillo, Knight M.L., Lin T.Y., Lin Y.C., Liu X., Ma C., McCauley J.W., Rijal P., Schimanski L., Shih S.R., Tan T.K., Townsend A.R.Fuentes:scopusBroadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents
ArticleAbstract: Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on humaPalabras claves:aptamer, covid-19, modified DNA, MT: Oligonucleotides, SARS-COV-2, SELEX, Therapies and Applications, variants of concern, viral neutralizationAutores:Chadwick J., Chase C.N., Gelinas A.D., Harding A.C., James W.S., Janjic N., Javier Gilbert Jaramillo, Lee T., Liu S., Otis M.R., Ream B.E., Schneider D.J., Tan T.K., Zhang C.Fuentes:scopusDivergent trajectories of antiviral memory after SARS-CoV-2 infection
ArticleAbstract: The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection aPalabras claves:Autores:Abuelgasim H., Adland E., Alexander F., Alhussni A., Ali M., Allott K., Arancibia-Cárcamo C.V., Azim Ansari M., Belij-Rammerstorfer S., Bibi S., Blackwell L., Borak M., Brown A., Brown H., Cassar M.P., Cavell B., Clutterbuck E.A., Conlon C.P., Cutteridge J., de Silva T.I., Deeks A.S., Denly L., Dimitriadis S., Dong T., Duncan C.J.A., Eyre D.W., Fassih S., Flaxman A., Foord T., Fordwoh T., Frater J., Fries A., Goulder P., Grist J., Hackstein C.P., Halkerston R., Harding A.C., Hill J., Ho L.P., Holmes J., Horsington B., James T., Javier Gilbert Jaramillo, Jay C., Jeffery K., Johnson S.A., Kerneis S., Kim D., Knight J.C., Kronsteiner B., Lambe T., Lie Y., Lillie K., Linder A., Longet S., Lumley S.F., Marinou S., Matthews P.C., Mellors J., Mentzer A.J., Moore S.C., Morrow J., Neubauer S., Ogbe A., O’Connor D., O’Donnell D., Pace M., Payne R.P., Peng Y., Petousi N., Petropoulos C., Pollard A.J., Raman B., Richter A., Ritter T.G., Rongkard P., Rowland-Jones S.L., Sedik C., Silva-Reyes L., Simmons B., Skelly D.T., Smith H., Stafford L., Stockdale L., Talbot N.P., Taylor A., Taylor S., Thomas S., Thomas S.R., Tipoe T., Tomic A., Travis S., Turtle L., Vieira V.A., Warren Y., Watson A.J.R., Weeks E., Wilson R., Wrin T., Young R.Fuentes:scopusG-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
ArticleAbstract: Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal demenPalabras claves:amyotrophic lateral sclerosis, C9orf72, frontotemporal dementia, G-quadruplexAutores:Abdelkarim S., Balendra R., Boykin D.W., Calvo A., Chio A., Clarke M., Clayton E.L., Farahat A.A., Fratta P., Heslegrave A., Houlden H., Isaacs A.M., Ismail M.A., Javier Gilbert Jaramillo, Konrad M.T., Mitchell J.S., Moens T.G., Neidle S., Niccoli T., Nicoll A.J., Parkinson G., Partridge L., Patani R., Polke J.M., Preza E., Simone R., Stephens C.E., Vo T., Wilson K.M., Wilson W.D., Woodling N.S., Wray S., Zetterberg H.Fuentes:scopusInclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity
ArticleAbstract: Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMPPalabras claves:cGAMP, Influenza a virus, SARS-COV-2, type I interferon, viral vaccine vectorAutores:Beveridge R., Borrow P., Bridgeman A., Chauveau L., Drakesmith H., Frost J.N., Javier Gilbert Jaramillo, Knight M.L., Liu X., Partridge T., Pedroza-Pacheco I., Rehwinkel J., Rijal P., Russell R.A., Tan T.K., Townsend A.R.Fuentes:scopusErratum: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans (PLoS Pathog (2021) 17:2 (e1009352) DOI: 10.1371/journal.ppat.1009352)
OtherAbstract: There is an error in the caption for S2 Fig.The cells in this experiment were transduced to expressPalabras claves:Autores:Chen C.P., Chen T.H., Cheng C.Y., Cheng S.H., Daniels R.S., Harding A.C., Harvey R., Huang C.G., Huang K.Y.A., Huang Y.C., Hussain S., James W.S., Jan J.T., Javier Gilbert Jaramillo, Knight M.L., Lin T.Y., Lin Y.C., Liu X., Ma C., McCauley J.W., Rijal P., Schimanski L., Shih S.R., Tan T.K., Townsend A.R.Fuentes:scopusErratum: Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium (Stem Cell Reports (2021) 16(7) (1735–1748), (S2213671121002691), (10.1016/j.stemcr.2021.05.018))
OtherAbstract: (Stem Cell Reports 16, 1735–1748; 2021) The authors would like to make two corrections to the supplePalabras claves:Autores:Browne C., Cowley S.A., Ebrahimi K.H., James W.S., Javier Gilbert Jaramillo, Pires E., Reardon P.K., Stodolak S., Vaughan-Jackson A.Fuentes:scopusInterferon-stimulated gene products as regulators of central carbon metabolism
ArticleAbstract: In response to viral infections, the innate immune system rapidly activates expression of several inPalabras claves:GAPDH, immunometabolism, ISG, viperin, virusesAutores:Ebrahimi K.H., James W.S., Javier Gilbert Jaramillo, McCullagh J.S.O.Fuentes:scopus