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Comparative Analysis of NADPH-Cytochrome P450 Reductases From Legumes for Heterologous Production of Triterpenoids in Transgenic Saccharomyces cerevisiae
ArticleAbstract: Triterpenoids are plant specialized metabolites with various pharmacological activities. They are wiPalabras claves:cytochrome P450 monooxygenases (CYP), heterologous production, Legumes, NADPH-cytochrome P450 reductases (CPR), Saccharomyces Cerevisiae, TriterpenoidsAutores:Chikugo A., Ery Odette Fukushima, Istiandari P., Muranaka T., Seki H., Srisawat P., Suzuki H., Tamura K., Yasumoto S.Fuentes:googlescopusAntioxidant and antimutagenic polyisoprenylated benzophenones and xanthones from Rheedia acuminata
ArticleAbstract: Dichloromethane extract of the stem bark of Rheedia acuminata yielded three benzophenones with antioPalabras claves:Acuminophenone A, Antimutagenicity, Antioxidant capacity, Formoxanthone C, Guttiferone K, Isoxanthochymol, Macluraxanthone, mutagenicity, polyisoprenylated benzophenones, Prenylated xanthones, Rheedia acuminataAutores:Akesson B., Almanza G.R., Ery Odette Fukushima, Mollinedo P., Quispe R., Rodrigo G., Sterner O., Villagomez R.Fuentes:googlescopusCYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis
ArticleAbstract: Triterpenoids are a diverse group of secondary metabolites that are associated with a variety of bioPalabras claves:CYP716As, Cyt P450 monooxygenase, Medicago truncatula, Triterpenoids, Vitis viníferaAutores:Ery Odette Fukushima, Mizutani M., Muranaka T., Ohyama K., Ono E., Saito K., Seki H., Umemoto N.Fuentes:googlescopusArtemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
ReviewAbstract: Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisiPalabras claves:Artemisia annua, Artemisinin, MALARIA, Metabolic engineering, Mode of action, Resistant parasitesAutores:Ery Odette Fukushima, Muangphrom P., Muranaka T., Seki H.Fuentes:googlescopusAllylic Hydroxylation Activity Is a Source of Saponin Chemodiversity in the Genus Glycyrrhiza
ArticleAbstract: Licorice (Glycyrrhiza) produces glycyrrhizin, a valuable triterpenoid saponin, which exhibits persisPalabras claves:Allylic hydroxylation, Chemodiversity, CYP88D subfamily, Cytochrome p450, Licorice, TriterpenoidAutores:Ery Odette Fukushima, Fanani M.Z., Ishimori M., Muranaka T., Ohyama K., Saito K., Sawai S., Seki H., Sudo H.Fuentes:googlescopusFunctional analysis of orthologous artemisinic aldehyde Δ11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing Artemisia absinthium
ArticleAbstract: Artemisinin is the most effective antimalarial compound isolated from Artemisia annua. Artemisinic aPalabras claves:ARTEMISIA ABSINTHIUM, Artemisinin, DBR2 ortholog, Dihydroartemisinic aldehyde, ReductaseAutores:Ery Odette Fukushima, Muangphrom P., Muranaka T., Seki H., Suzuki M.Fuentes:googlescopusFunctional characterization of CYP716 family P450 enzymes in triterpenoid biosynthesis in tomato
ArticleAbstract: Triterpenoids are a group of structurally diverse specialized metabolites that frequently show usefuPalabras claves:C-28 oxidase, C-6β oxidase, CYP716 family, cytochrome P450 monooxygenase, Tomato, Triterpenoid biosynthesisAutores:Ery Odette Fukushima, Muranaka T., Seki H., Shimizu Y., Yasumoto S.Fuentes:googlescopusIdentification and characterization of a novel sesquiterpene synthase, 4-amorphen-11-ol synthase, from artemisia maritima
ArticleAbstract: Artemisinin, a sesquiterpene lactone exhibiting effective antimalarial activity, is produced by onlyPalabras claves:4-amorphen-11-ol, 4-amorphen-11-ol synthase, Artemisia maritima, Artemisinin, Sesquiterpene synthaseAutores:Ery Odette Fukushima, Matsumoto S., Muangphrom P., Muranaka T., Nishiwaki M., Seki H.Fuentes:googlescopusIdentification of key amino acid residues toward improving the catalytic activity and substrate specificity of plant-derived cytochrome P450 monooxygenases CYP716A subfamily enzyme for triterpenoid production in Saccharomyces cerevisiae
ArticleAbstract: Triterpenoids constitute a group of specialized plant metabolites with wide structural diversity andPalabras claves:bioinformatics, CYP716A, cytochrome P450 monooxygenase, in vivo functional analysis, protein engineering, triterpene oxidaseAutores:Ery Odette Fukushima, Muranaka T., Romsuk J., Seki H., Yasumoto S.Fuentes:googlescopusIdentification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant α-amyrin-producing activity
ArticleAbstract: Triterpenoids are widely distributed among plants of the legume family. However, most studies have fPalabras claves:Bauhinia forficata, non-model legume, oxidosqualene cyclase, Triterpenoid, α-amyrinAutores:Ery Odette Fukushima, Muranaka T., Robertlee J., Seki H., Srisawat P., Suzuki H., Yasumoto S.Fuentes:googlescopus