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Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast
ArticleAbstract: Triterpenoid saponins are a diverse group of specialized (secondary) metabolites with many biologicaPalabras claves:4-epi-hederagenin, Combinatorial biosynthesis, CYP72A, cytochrome P450 monooxygenase, Gypsogenic acid, Medicago truncatula, Soyasapogenol BAutores:Ery Odette Fukushima, Muranaka T., Ohyama K., Saito K., Sawai S., Seki H., Suzuki M.Fuentes:googlescopusComparative Analysis of NADPH-Cytochrome P450 Reductases From Legumes for Heterologous Production of Triterpenoids in Transgenic Saccharomyces cerevisiae
ArticleAbstract: Triterpenoids are plant specialized metabolites with various pharmacological activities. They are wiPalabras claves:cytochrome P450 monooxygenases (CYP), heterologous production, Legumes, NADPH-cytochrome P450 reductases (CPR), Saccharomyces Cerevisiae, TriterpenoidsAutores:Chikugo A., Ery Odette Fukushima, Istiandari P., Muranaka T., Seki H., Srisawat P., Suzuki H., Tamura K., Yasumoto S.Fuentes:googlescopusComparative analysis of CYP716A subfamily enzymes for the heterologous production of C-28 oxidized triterpenoids in transgenic yeast
ArticleAbstract: Several enzymes of the CYP716A subfamily have been reported to be involved in triterpenoid biosynthePalabras claves:Beta Vulgaris, Coffea Arábica, CYP716A, Olea europaea, TriterpenoidAutores:Ery Odette Fukushima, Muranaka T., Ohyama K., Seki H., Suzuki H., Umemoto N.Fuentes:googlescopusAtrazine exposed phytoplankton causes the production of non-viable offspring on Daphnia magna
ArticleAbstract: This study focuses on the possibility that herbicide-exposed phytoplankton will cause sub-lethal effPalabras claves:Atrazine, Daphnia magna, Raphidocelis subcapitata, Risk Assessment, sublethal effectsAutores:Ery Odette Fukushima, Kato Y., Matsuura T., Muranaka T., Religia P., Watanabe H.Fuentes:googlescopusAntioxidant and antimutagenic polyisoprenylated benzophenones and xanthones from Rheedia acuminata
ArticleAbstract: Dichloromethane extract of the stem bark of Rheedia acuminata yielded three benzophenones with antioPalabras claves:Acuminophenone A, Antimutagenicity, Antioxidant capacity, Formoxanthone C, Guttiferone K, Isoxanthochymol, Macluraxanthone, mutagenicity, polyisoprenylated benzophenones, Prenylated xanthones, Rheedia acuminataAutores:Akesson B., Almanza G.R., Ery Odette Fukushima, Mollinedo P., Quispe R., Rodrigo G., Sterner O., Villagomez R.Fuentes:googlescopusCYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis
ArticleAbstract: Triterpenoids are a diverse group of secondary metabolites that are associated with a variety of bioPalabras claves:CYP716As, Cyt P450 monooxygenase, Medicago truncatula, Triterpenoids, Vitis viníferaAutores:Ery Odette Fukushima, Mizutani M., Muranaka T., Ohyama K., Ono E., Saito K., Seki H., Umemoto N.Fuentes:googlescopusArtemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
ReviewAbstract: Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisiPalabras claves:Artemisia annua, Artemisinin, MALARIA, Metabolic engineering, Mode of action, Resistant parasitesAutores:Ery Odette Fukushima, Muangphrom P., Muranaka T., Seki H.Fuentes:googlescopusAllylic Hydroxylation Activity Is a Source of Saponin Chemodiversity in the Genus Glycyrrhiza
ArticleAbstract: Licorice (Glycyrrhiza) produces glycyrrhizin, a valuable triterpenoid saponin, which exhibits persisPalabras claves:Allylic hydroxylation, Chemodiversity, CYP88D subfamily, Cytochrome p450, Licorice, TriterpenoidAutores:Ery Odette Fukushima, Fanani M.Z., Ishimori M., Muranaka T., Ohyama K., Saito K., Sawai S., Seki H., Sudo H.Fuentes:googlescopusFunctional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species: The discovery of novel koidzumiol and (+)-a-Bisabolol synthases
ArticleAbstract: The production of artemisinin, the most effective antimalarial compound, is limited to Artemisia annPalabras claves:(+)-a-Bisabolol, Amorpha-4,11-diene synthase, ARTEMISIA ABSINTHIUM, Artemisia kurramensis, Artemisia maritime, KoidzumiolAutores:Ery Odette Fukushima, Komori A., Mikawa R., Muangphrom P., Muranaka T., Nishiwaki M., Seki H., Suzuki M.Fuentes:googlescopusFunctional analysis of orthologous artemisinic aldehyde Δ11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing Artemisia absinthium
ArticleAbstract: Artemisinin is the most effective antimalarial compound isolated from Artemisia annua. Artemisinic aPalabras claves:ARTEMISIA ABSINTHIUM, Artemisinin, DBR2 ortholog, Dihydroartemisinic aldehyde, ReductaseAutores:Ery Odette Fukushima, Muangphrom P., Muranaka T., Seki H., Suzuki M.Fuentes:googlescopus