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Hexafluoroacetone as a protecting and activating reagent: Synthesis of new types of fluoro-substituted α-amino, α-hydroxy and α-mercapto acids
ArticleAbstract: Starting from (S)-aspartic, (S)-malic, (S)-citramalic and (S,R)-thiomalic acid, new types of 4,4-difPalabras claves:amino acids, Fluorine, Hydroxy acids, Mercapto acids, PeptidesAutores:Berger S., Burger K., El-Kousy S.M., Hennig L., Jan Spengler, Koksch B., Lange T., Osipov S.N., Tsouker P.Fuentes:googlescopusIncorporation of the α-mercapto acid unit into peptides
ArticleAbstract: Incorporation of α-mercapto acid units into the backbone of potential drug candidates improves the mPalabras claves:Acylations, Dielectrophiles, Hexafluoroacetone, Peptides, Thiols, Thiomalic acidAutores:Alberício F., Burger K., Haas A., Jan Spengler, Pumpor K.Fuentes:googlescopusK-Oxyma: A strong acylation-promoting, 2-ctc resin-friendly coupling additive
ArticleAbstract: Here we present a new formulation of the recently introduced OxymaPure additive for peptide bond forPalabras claves:Acid-labile solid supports, acylation, Peptides, solid-phase synthesisAutores:Acosta G.A., Alberício F., Cherkupally P., El-Faham A., Hortensia Rodriguez Cabrera, Jan Spengler, Khattab S.N., Luxembourg Y., Nieto-Rodriguez L., Prohens R., Shamis M., Subiros-Funosas R.Fuentes:scopusThe potential of N-alkoxymethyl groups as peptide backbone protectants
ArticleAbstract: In this study, the potential of N-alkoxymethyl groups as protectants for the peptide backbone has bePalabras claves:Backbone N-alkylation, Backbone protecting groups, N-Alkoxymethyl, Peptides, SPPSAutores:Alberício F., Fernandez-Llamazares A.I., Jan SpenglerFuentes:googlescopus