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Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology(2)
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CoaTx-II, a new dimeric Lys49 phospholipase A<inf>2</inf> from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles
ArticleAbstract: Snake venoms are rich and intriguing sources of biologically-active molecules that act on target celPalabras claves:Antibacterial effect, Crotalus oreganus abyssus, Lys49 phospholipase A 2, Myotoxicity, Snake venomAutores:de Azevedo Calderon L., González W., José Rafael de Almeida, Lancellotti M., Marangoni S., Ramírez D., Saulo L. Silva, Soares A.M.Fuentes:googlescopusAssessing the stability of historical and desiccated snake venoms from a medically important Ecuadorian collection
ArticleAbstract: Bothrops asper and Bothrops atrox are important venomous snakes from Ecuador responsible for the mosPalabras claves:Desiccated venom, Proteomic, Snake venom, stability, ToxicologicalAutores:Bruno Mendes, Caldeira C.A.S., Fausto Zaruma-Torres, José Rafael de Almeida, Laines J., Noroska Gabriela Salazar Mogollón, Pico J., Ricardo S.P. Patiño, Saulo L. Silva, Terán M.Fuentes:googlescopusBiochemical and functional studies of ColTx-I, a new myotoxic phospholipase A<inf>2</inf> isolated from Crotalus oreganus lutosus (Great Basin rattlesnake) snake venom
ArticleAbstract: Commonly, phospholipases A2 (PLA2s) play key roles in the pathogenesis of the local tissue damage chPalabras claves:Biological activities, Crotalus oreganus lutosus, Myotoxin, Phospholipase A 2, Snake venomAutores:de Azevedo Calderon L., José Rafael de Almeida, Marangoni S., Resende L.M., Ribeiro R.I.M.A., Saulo L. Silva, Silva A.G., Soares A.M., Stábeli R.G.Fuentes:scopusBothrops atrox from Ecuadorian Amazon: Initial analyses of venoms from individuals
ArticleAbstract: Bothrops atrox is the most clinically relevant snake species within the Amazon region, which includePalabras claves:antivenom, Enzymatic, Lethality, Phenotype, ToxicologicalAutores:Bruno Mendes, Carolina Proaño-Bolaños, David Salazar-Valenzuela, Evencio Joel Medina-Villamizar, José Rafael de Almeida, Ricardo S.P. Patiño, Saulo L. SilvaFuentes:googlescopusAnti-platelet aggregation activity of two novel acidic Asp49-phospholipases A<inf>2</inf> from Bothrops brazili snake venom
ArticleAbstract: Phospholipases A2 (PLA2s) are important enzymes present in snake venoms and are related to a wide spPalabras claves:Acidic phospholipases A 2, Anti-platelet aggregation activity, Bothrops brazili, Snake venomAutores:Alfonso J.J., Fuly A.L., Gómez A.F., Gomez M.C.V., José Rafael de Almeida, Kayano A.M., Moura L.A., Oliveira E., Saulo L. Silva, Simões-Silva R., Soares A.M., Sobrinho J.C., Souza V.R., Zanchi F.B., Zuliani J.P.Fuentes:googlescopusCruzioseptins, antibacterial peptides from Cruziohyla calcarifer skin, as promising leishmanicidal agents
ArticleAbstract: Screenings of natural products have significantly contributed to the discovery of novel leishmanicidPalabras claves:Cruzioseptins, Frog skin secretion, Leishmanicidal, PeptidesAutores:Bruno Mendes, Carolina Proaño-Bolaños, Gadelha F.R., José Rafael de Almeida, Miguel D.C.Fuentes:googlescopusDeciphering the Limitations and Antibacterial Mechanism of Cruzioseptins
ArticleAbstract: Antimicrobial peptides consist mainly of membrane-active sequences, which are potentially relevant tPalabras claves:Antimicrobial, Membranolytic, Peptides, Physiological conditionAutores:Carolina Proaño-Bolaños, Fernando Valdivieso-Rivera, José Rafael de Almeida, Sebastián Bermúdez-PugaFuentes:scopusGenetic and phenotypic diversity of Rhizobium isolates from southern Ecuador
ArticleAbstract: Rhizobium-legume symbioses play relevant roles in agriculture but have not been well studied in EcuaPalabras claves:16S rRNA gene, Diazotrophic bacteria, Indole acetic acid, Nodulation, Phaseolus vulgarisAutores:Alvarado-Capó Y., Aminael Sánchez-Rodríguez, José Rafael de Almeida, Klever Iván Granda-Mora, Noroska Gabriela Salazar Mogollón, Roldán Torres GutiérrezFuentes:scopusDissection of phospholipases A<inf>2</inf> reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria
ArticleAbstract: Cationic peptides bio-inspired by natural toxins have been recognized as an efficient strategy for tPalabras claves:Antimicrobial, Cationic, Cytotoxicity, Leishmanicidal activity, Snake venomAutores:Bruno Mendes, Carolina Proaño-Bolaños, Cristóbal Leonardo Domínguez-Borbor, Edgar A. Pinos-Tamayo, José Rafael de Almeida, Maria S. Peña-Carrillo, Miguel D.C.Fuentes:googlescopusInspiration from cruzioseptin-1: membranolytic analogue with improved antibacterial properties
ArticleAbstract: Peptide engineering has gained attraction as a source of new cationicity-enhanced analogues with higPalabras claves:Antimicrobial peptides, Cruzioseptin, Membranolytic effect, Rational designAutores:Carolina Proaño-Bolaños, Espinosa de los Monteros-Silva N., Fernanda Toscano, Giovanna Morán-Marcillo, José Rafael de Almeida, Karla Sofía Vizuete Armendáriz, Karla Vizuete, marbel torres arias, Naranjo R.E., Sebastián Bermúdez-PugaFuentes:googlescopus