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Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity
ArticleAbstract: Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amiPalabras claves:branched-chain amino acid biosynthesis, Drug Discovery, Herbicide, ketol-acid reductoisomerase, transition state analogueAutores:David A. Terán, Guddat L.W., Kandale A., Lv Y., Mario Daniel García, McGeary R.P., Patel K.M., Schembri M.A., Schenk G., Zheng S.Fuentes:scopusCrystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase
ArticleAbstract: Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoanPalabras claves:Autores:Česnek M., David A. Terán, Guddat L.W., Hocková D., Keough D.T., Naesens L., Zíková A.Fuentes:scopusCrystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP
ArticleAbstract: The 6-oxopurine phosphoribosyltransferases (PRTs) are drug targets for the treatment of parasitic diPalabras claves:6-oxopurine phosphoribosyltransferase, GMP, IMP, purine salvage, Trypanosoma brucei, XMPAutores:David A. Terán, Doleželová E., Guddat L.W., Hocková D., Keough D.T., Zíková A.Fuentes:scopusAcyclic nucleoside phosphonates as possible chemotherapeutics against Trypanosoma brucei
ReviewAbstract: Human African trypanosomiasis is a life-threatening illness caused by Trypanosoma brucei. Owing to tPalabras claves:Autores:David A. TeránFuentes:scopusEvaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery
ArticleAbstract: Due to toxicity and compliance issues and the emergence of resistance to current medications new druPalabras claves:Autores:David A. Terán, Doleželová E., Gahura O., Guddat L.W., Hocková D., Keough D.T., Kotrbová Z., Procházková M., Špaček P., Zíková A.Fuentes:scopusDynamics of Sylvatic Chagas Disease Vectors in Coastal Ecuador Is Driven by Changes in Land Cover
ArticleAbstract: Background:Chagas disease is a serious public health problem in Latin America where about ten millioPalabras claves:Autores:David A. Terán, Mario J. Grijalva, Olivier J. DanglesFuentes:scopusShelf life estimation of Blackberry (Rubus glaucus Benth) with bacterial cellulose film coating from Komagataeibacter xylinus
ArticleAbstract: The Castile blackberry (Rubus glaucus Benth) is an Andean crop with nutritional and antioxidant propPalabras claves:bacterial cellulose, biofilm, Castile blackberry, CoatingAutores:David A. Terán, Debut Alexis, Jonatan A. Toscano Ávila, Karla Sofía Vizuete Armendáriz, Karla Vizuete, Liliana A. Cerda-Mejía, Martínez J.Fuentes:googlescopus