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Current and experimental antibody-based therapeutics: Insights, breakthroughs, setbacks and future directions
ArticleAbstract: The premise of targeted therapy was born from an intimate understanding of the unique biological patPalabras claves:antibody, Antibody based therapeutics, Antithrombotic agents, Immune response, monoclonal antibodiesAutores:Enma Verónica Páez-Espinosa, Khasawneh F.T., Lin O.A., Murad J.P.Fuentes:scopusMouse transient receptor potential channel 6: Role in hemostasis and thrombogenesis
ArticleAbstract: Although changes in the intracellular levels of calcium (Ca2+) are a central step in platelet activaPalabras claves:Calcium entry, Hemostasis, Platelet aggregation, thrombogenesis, Transient receptor potential channel 6Autores:Enma Verónica Páez-Espinosa, Khasawneh F.T., Murad J.P., Ting H.J.Fuentes:googlescopusMouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function
ArticleAbstract: While changes in intracellular calcium levels is a central step in platelet activation and thrombusPalabras claves:Calcium channel, Platelets, Receptor-operated calcium entry, TRPC6Autores:Alshbool F., Enma Verónica Páez-Espinosa, Karim Z., Khasawneh F.T., Lin O.A.Fuentes:googlescopusInsulin receptor has tyrosine kinase activity toward Shc in rat liver
ArticleAbstract: Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues ofPalabras claves:Insulin action, insulin receptor, Shc, Tyrosine kinase activityAutores:Carvalho C.R.O., Enma Verónica Páez-Espinosa, Saad M.J.A., Velloso L.A.Fuentes:googlescopusInsulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats
ArticleAbstract: Insulin stimulates rapid tyrosine phosphorylation of the protein Shc, which subsequently binds to GrPalabras claves:DIABÉTES, Fasting, hyperinsulinemia, Hypoinsulinemia, p52Shc, Shc-Grb 2 associationAutores:Boschero A.C., Enma Verónica Páez-Espinosa, Rocha E.M., Saad M.J.A., Velloso L.A.Fuentes:googlescopusInvestigation of a thromboxane A<inf>2</inf> receptor–based vaccine for managing thrombogenesis
ArticleAbstract: Background—Despite the well-established role for the thromboxane A2 receptor (TPR) in the developmenPalabras claves:Antiplatelet agent, Platelets, Thrombosis, Thromboxane A receptor 2, VaccineAutores:Alshbool F., Enma Verónica Páez-Espinosa, Karim Z., Khasawneh F.T., Lin O.A.Fuentes:googlescopusRegulation of insulin-stimulated tyrosine phosphorylation of Shc and IRS-1 in the muscle of rats: Effect of growth hormone and epinephrine
ArticleAbstract: Insulin receptor substrate-1 (IRS-1) and Shc protein have the same binding site at the insulin recepPalabras claves:Epinephrine, Growth hormone, Insulin signal transductionAutores:Carvalho C.R.O., Enma Verónica Páez-Espinosa, Saad M.J.A., Thirone A.C.P.Fuentes:googlescopusThe role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior
Book PartAbstract: There is a strong association between the increased expression of ATP-binding cassette (ABC) transpoPalabras claves:ATP-binding cassette transporters, BRAF gene, EMT process, Metástasis, Sodium/iodide symporter, Thyroid carcinomaAutores:Corcoy R., Enma Verónica Páez-Espinosa, Escolà-Gil J.C., Fuste V., Julve J., Lerma E., Mato E., Moral A., Pérez J.I., Revilla G.Fuentes:scopus