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Farmacología y terapéutica(5)
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scopus(5)
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. ThPalabras claves:Drug Discovery, natural product analogues, trypanosomatids, [3+2] cycloadditionAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Morris J.C., Smith T.K., Stefanie K. Menzies, Thomson M.I., Tulloch L.B., Zacharova M.K.Fuentes:scopusDesign and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern thaPalabras claves:chemical tools, drug design, Natural products, photoaffinity, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusDirect and indirect approaches to identify drug modes of action
ReviewAbstract: Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drPalabras claves:affinity chromatography, drug mode of action, Genomics, Metabolomics, photo-affinity labeling, proteomics, target ID, transcriptomicsAutores:Coron R.P., Florence G.J., Roberts M.D., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusIn vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus
ArticleAbstract: Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming byPalabras claves:Boomslang, drugs, Small molecules, snakebite, SVMPAutores:Alsolaiss J., Casewell N.R., Clare R.H., Crittenden E., Edge R.J., Hall S.R., Harrison R.A., Kool J., Marriott A.E., Stefanie K. Menzies, Westhorpe A., Xie C.Fuentes:scopusSimplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins
ArticleAbstract: The need for new treatments for the neglected tropical diseases African sleeping sickness, Chagas diPalabras claves:Acetogenins, Natural products, neglected tropical diseases, TetrahydropyranAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopus