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scopus(4)
Direct and indirect approaches to identify drug modes of action
ReviewAbstract: Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drPalabras claves:affinity chromatography, drug mode of action, Genomics, Metabolomics, photo-affinity labeling, proteomics, target ID, transcriptomicsAutores:Coron R.P., Florence G.J., Roberts M.D., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusPhoto-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues
ArticleAbstract: Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently requiPalabras claves:Autores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusStructure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase
ArticleAbstract: The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible foPalabras claves:biological activity, drug design, FoF1-ATP synthase, homogeneous catalysis, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusThe trypanosome alternative oxidase: A potential drug target?
ReviewAbstract: New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgePalabras claves:chemotherapy, Drug Discovery, human African trypanosomiasis, Sleeping sickness, Trypanosoma brucei, Trypanosome alternative oxidaseAutores:Florence G.J., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopus