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PLoS Neglected Tropical Diseases(2)
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Microorganismos, hongos y algas(6)
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ODS 3: Salud y bienestar(11)
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scopus(11)
Direct and indirect approaches to identify drug modes of action
ReviewAbstract: Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drPalabras claves:affinity chromatography, drug mode of action, Genomics, Metabolomics, photo-affinity labeling, proteomics, target ID, transcriptomicsAutores:Coron R.P., Florence G.J., Roberts M.D., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusA broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania
ArticleAbstract: Glycoconjugates play major roles in the infectious cycle of the trypanosomatid parasite Leishmania.Palabras claves:chemotherapy, Fucose, Glycobiology, Glycosyltransferase, Trypanosomatid protozoan parasitesAutores:Beverley S.M., Damerow S., Ferguson M.A.J., Guo H., Penha L., Polanco G., Stefanie K. Menzies, Zegzouti H.Fuentes:scopusAn analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management
ArticleAbstract: Background The World Health Organization’s strategy to halve snakebite mortality and morbidity by 20Palabras claves:Autores:Ainsworth S., Casewell N.R., Harrison R.A., Stefanie K. MenziesFuentes:scopusDesign and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern thaPalabras claves:chemical tools, drug design, Natural products, photoaffinity, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusPhoto-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues
ArticleAbstract: Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently requiPalabras claves:Autores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusSaliva alternative to upper respiratory swabs for SARS-CoV-2 diagnosis
ArticleAbstract: PCR of upper respiratory specimens is the diagnostic standard for severe acute respiratory syndromePalabras claves:Autores:Adams E.R., Aljayyoussi G., Brown L., Byrne R.L., Collins A.M., Cubas-Atienzar A.I., Cuevas L.E., Ferreira D.M., Fletcher T.E., Fraser A.J., Garrod G., Hill H., Hughes G.L., Hyder-Wright A., Kay G.A., Kontogianni K., Mitsi E., Owen S.I., Patterson E.I., Stefanie K. Menzies, Todd S., Williams C.T.Fuentes:scopusSelf-sampling of capillary blood for SARS-CoV-2 serology
ArticleAbstract: Serological testing is emerging as a powerful tool to progress our understanding of COVID-19 exposurPalabras claves:Autores:Adams E.R., Brown L., Byrne R.L., Cubas-Atienzar A.I., Cuevas L.E., Fitchett J.R.A., Fletcher T.E., Fraser A.J., Garrod G., Kay G.A., Kontogianni K., Krishna S., Owen S.I., Planche T., Sainter C., Staines H.M., Stefanie K. Menzies, Turtle L., Williams C.T.Fuentes:scopusSimplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins
ArticleAbstract: The need for new treatments for the neglected tropical diseases African sleeping sickness, Chagas diPalabras claves:Acetogenins, Natural products, neglected tropical diseases, TetrahydropyranAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusStructure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase
ArticleAbstract: The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible foPalabras claves:biological activity, drug design, FoF1-ATP synthase, homogeneous catalysis, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusSARS-CoV-2 enzyme-linked immunosorbent assays as proxies for plaque reduction neutralisation tests
ArticleAbstract: Severe acute respiratory coronavirus 2 (SARS-CoV-2) has spread globally since its emergence in 2019.Palabras claves:Autores:Adams E.R., Clark D.J., Cuevas L.E., Davies B.M.O., Eckersley N.M., Giorgi E., Hughes G.L., Kay G.A., Kirwan D.E., Krishna S., Owen S.I., Patterson E.I., Planche T., Staines H.M., Stefanie K. Menzies, Williams C.T.Fuentes:scopus