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PLoS Neglected Tropical Diseases(5)
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An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management
ArticleAbstract: Background The World Health Organization’s strategy to halve snakebite mortality and morbidity by 20Palabras claves:Autores:Ainsworth S., Casewell N.R., Harrison R.A., Stefanie K. MenziesFuentes:scopusAnimal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19
OtherAbstract: Published data on the first 5,000 coronavirus patients to receive plasma shows promise in the UnitedPalabras claves:Antibodies, covid19, hyper-immune sera, Plasma, therapyAutores:Ainsworth S., Pleass R.J., Stefanie K. MenziesFuentes:scopusA broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania
ArticleAbstract: Glycoconjugates play major roles in the infectious cycle of the trypanosomatid parasite Leishmania.Palabras claves:chemotherapy, Fucose, Glycobiology, Glycosyltransferase, Trypanosomatid protozoan parasitesAutores:Beverley S.M., Damerow S., Ferguson M.A.J., Guo H., Penha L., Polanco G., Stefanie K. Menzies, Zegzouti H.Fuentes:scopusDevelopment of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. ThPalabras claves:Drug Discovery, natural product analogues, trypanosomatids, [3+2] cycloadditionAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Morris J.C., Smith T.K., Stefanie K. Menzies, Thomson M.I., Tulloch L.B., Zacharova M.K.Fuentes:scopusDesign and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern thaPalabras claves:chemical tools, drug design, Natural products, photoaffinity, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusExploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms
ArticleAbstract: Snakebite is a neglected tropical disease that causes high rates of global mortality and morbidity.Palabras claves:antivenom, immunogen, neglected tropical diseases, polyclonal antibodies, recombinant expression, serine proteases, snake venom toxin, snakebiteAutores:Ainsworth S., Alomran N., Alsolaiss J., Blundell P., Casewell N.R., Crittenden E., Dawson C.A., Edge R.J., Hall S.R., Harrison R.A., Stefanie K. Menzies, Wilkinson M.C.Fuentes:scopusDirect and indirect approaches to identify drug modes of action
ReviewAbstract: Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drPalabras claves:affinity chromatography, drug mode of action, Genomics, Metabolomics, photo-affinity labeling, proteomics, target ID, transcriptomicsAutores:Coron R.P., Florence G.J., Roberts M.D., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusNon-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors
ArticleAbstract: Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrPalabras claves:acetogenin, Human African Trypanosomiasis (HAT), natural product analogues, Neglected diseases, stereochemistry, Trypanosoma bruceiAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Morris J.C., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusIn vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus
ArticleAbstract: Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming byPalabras claves:Boomslang, drugs, Small molecules, snakebite, SVMPAutores:Alsolaiss J., Casewell N.R., Clare R.H., Crittenden E., Edge R.J., Hall S.R., Harrison R.A., Kool J., Marriott A.E., Stefanie K. Menzies, Westhorpe A., Xie C.Fuentes:scopusIgg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection
ArticleAbstract: We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SPalabras claves:Autores:Adams E.R., Augustin Y., Byrne R.L., Clark D.J., Cocozza M., Cubas-Atienzar A.I., Cuevas L.E., Cusinato M., Davies B.M.O., Davis M., Davis P., Duvoix A., Eckersley N.M., Fitchett J.R.A., Forton D., Fraser A.J., Garrod G., Hadcocks L., Hu Q., Johnson M., Kay G.A., Kirwan D.E., Klekotko K., Krishna S., Lewis Z., Macallan D.C., Mensah-Kane J., Monahan I., Moore C.M., Nebe-Von-Caron G., Owen S.I., Planche T., Sainter C., Sall A.A., Schouten J., Staines H.M., Stefanie K. Menzies, Wilkins J., Williams C.T., Woolston K.Fuentes:scopus