Mostrando 7 resultados de: 7
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Cáncer(5)
Biología molecular(2)
Biotecnología(2)
Bioquímica(1)
Medicina molecular(1)
Origen
scopus(7)
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
ArticleAbstract: Targeted cancer therapies, although often effective, have limited utility owing to preexisting primaPalabras claves:Autores:Bader A.G., Chen X., Dysart S., Esteban A. Orellana, Kasinski A.L., Kelnar K., Shimer E., Slack F.J., Stahlhut C., Zhao J.Fuentes:scopusFolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
ArticleAbstract: MicroRNAs are small RNAs that negatively regulate gene expression posttranscriptionally. Because chaPalabras claves:Autores:Esteban A. Orellana, Kasinski A.L., Low P.S., Lyle L.T., Rangasamy L., Tenneti S.Fuentes:scopusMETTL1-mediated m<sup>7</sup>G modification of Arg-TCT tRNA drives oncogenic transformation
ArticleAbstract: The emerging “epitranscriptomics” field is providing insights into the biological and pathological rPalabras claves:Arg-TCT, Cáncer, m G 7, METTL1, N -methylguanosine 7, oncogene, translation, tRNAAutores:Ali R., Aspris D., Bernardes G.J.L., Bradley A., De Braekeleer E., Esteban A. Orellana, Fischer E.S., Garyfallos D.A., Gregory R.I., Gu M., Gutierrez A., Lim J., Liu Q., Mikutis S., Pirouz M., Sendinc E., Slack F.J., Tzelepis K., Vassiliou G.S., Yankova E., Zhang W.Fuentes:scopusIdentification and validation of microRNAs that synergize with miR-34a–a basis for combinatorial microRNA therapeutics
ArticleAbstract: Efforts to search for better treatment options for cancer have been a priority, and due to these effPalabras claves:combinatorial therapeutics, miR-34, miR-34a, miRNA therapeutics, Mirna-34, synergismAutores:Esteban A. Orellana, Kasinski A.L., Li C., Lisevick A.Fuentes:scopusMicrornas in cancer: A historical perspective on the path from discovery to therapy
ReviewAbstract: Recent progress in microRNA (miRNA) therapeutics has been strongly dependent on multiple seminal disPalabras claves:Cáncer, History, microRNA, therapeuticsAutores:Esteban A. Orellana, Kasinski A.L.Fuentes:scopustRNA dysregulation and disease
ReviewAbstract: tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in proteiPalabras claves:Autores:Esteban A. Orellana, Gregory R.I., Siegal E.Fuentes:scopusSynthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
ArticleAbstract: Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical prPalabras claves:acute leukemia, asparaginase, asparagine, Drug resistance, FBXW7, GSK3, proteasomal degradation, protein ubiquitination, synthetic lethality, Wnt signalingAutores:Bauer D.E., Degar J., Esteban A. Orellana, Gregory R.I., Gutierrez A., Hinze L., Karim S., McGuckin C., Neuberg D.S., Pfirrmann M., Sacher J., Stanulla M., Stegmaier K., Stevenson K.E., Vinjamur D., Wagner F.F.Fuentes:scopus