Documentos de Esteban A. Orellana | REDI

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Área temáticas: "Farmacología y terapéutica"

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Molecular Therapy - Nucleic Acids(1)

Nature Reviews Genetics(1)

Área temáticas

Enfermedades(5)

Fisiología humana(2)

Fisiología y materias afines(1)

Medicina y salud(1)

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Biología molecular(3)

Biotecnología(2)

Medicina molecular(1)

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Drug resistance(1)

A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer

Abstract: Targeted cancer therapies, although often effective, have limited utility owing to preexisting prima

Palabras claves:

Bader A.G., Chen X., Dysart S., Esteban A. Orellana, Kasinski A.L., Kelnar K., Shimer E., Slack F.J., Stahlhut C., Zhao J.

FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer

Abstract: MicroRNAs are small RNAs that negatively regulate gene expression posttranscriptionally. Because cha

Palabras claves:

Esteban A. Orellana, Kasinski A.L., Low P.S., Lyle L.T., Rangasamy L., Tenneti S.

Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin

Abstract: The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehic

Palabras claves:

DELIVERY, endosomal escape, folate, folate-conjugates, ligand, microRNA, miR-34, nigericin

Abdelaal A.M., Esteban A. Orellana, Kasinski A.L., Low P.S., Myoung S., Rangasamy L., Tenneti S.

Identification and validation of microRNAs that synergize with miR-34a–a basis for combinatorial microRNA therapeutics

Abstract: Efforts to search for better treatment options for cancer have been a priority, and due to these eff

Palabras claves:

combinatorial therapeutics, miR-34, miR-34a, miRNA therapeutics, Mirna-34, synergism

Esteban A. Orellana, Kasinski A.L., Li C., Lisevick A.

tRNA dysregulation and disease

Abstract: tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in protei

Palabras claves:

Esteban A. Orellana, Gregory R.I., Siegal E.

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Abstract: Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical pr

Palabras claves:

acute leukemia, asparaginase, asparagine, Drug resistance, FBXW7, GSK3, proteasomal degradation, protein ubiquitination, synthetic lethality, Wnt signaling

Bauer D.E., Degar J., Esteban A. Orellana, Gregory R.I., Gutierrez A., Hinze L., Karim S., McGuckin C., Neuberg D.S., Pfirrmann M., Sacher J., Stanulla M., Stegmaier K., Stevenson K.E., Vinjamur D., Wagner F.F.