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scopus(10)
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
ArticleAbstract: Targeted cancer therapies, although often effective, have limited utility owing to preexisting primaPalabras claves:Autores:Bader A.G., Chen X., Dysart S., Esteban A. Orellana, Kasinski A.L., Kelnar K., Shimer E., Slack F.J., Stahlhut C., Zhao J.Fuentes:scopusFolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
ArticleAbstract: MicroRNAs are small RNAs that negatively regulate gene expression posttranscriptionally. Because chaPalabras claves:Autores:Esteban A. Orellana, Kasinski A.L., Low P.S., Lyle L.T., Rangasamy L., Tenneti S.Fuentes:scopusEnhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin
ArticleAbstract: The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehicPalabras claves:DELIVERY, endosomal escape, folate, folate-conjugates, ligand, microRNA, miR-34, nigericinAutores:Abdelaal A.M., Esteban A. Orellana, Kasinski A.L., Low P.S., Myoung S., Rangasamy L., Tenneti S.Fuentes:scopusIdentification and validation of microRNAs that synergize with miR-34a–a basis for combinatorial microRNA therapeutics
ArticleAbstract: Efforts to search for better treatment options for cancer have been a priority, and due to these effPalabras claves:combinatorial therapeutics, miR-34, miR-34a, miRNA therapeutics, Mirna-34, synergismAutores:Esteban A. Orellana, Kasinski A.L., Li C., Lisevick A.Fuentes:scopusMETTL4 is an snRNA m<sup>6</sup>Am methyltransferase that regulates RNA splicing
OtherAbstract:Palabras claves:Autores:Chen H., Esteban A. Orellana, Gregory R.I., Gu L., Guo J., Liu Q., Shen Z., Shi Y., Wang L., Wang Y., Wu H., Xing Y.Fuentes:scopusMicrornas in cancer: A historical perspective on the path from discovery to therapy
ReviewAbstract: Recent progress in microRNA (miRNA) therapeutics has been strongly dependent on multiple seminal disPalabras claves:Cáncer, History, microRNA, therapeuticsAutores:Esteban A. Orellana, Kasinski A.L.Fuentes:scopusNew Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K<sup>+</sup>/H<sup>+</sup> Exchange
ArticleAbstract: Although peptides, antibodies/antibody fragments, siRNAs, antisense DNAs, enzymes, and aptamers arePalabras claves:Autores:Bandara N.A., Chelvam V., Esteban A. Orellana, Kanduluru A.K., Kasinski A.L., Low P.S., Rangasamy L., Srinivasarao M., You F.Fuentes:scopusStructural basis of regulated m<sup>7</sup>G tRNA modification by METTL1–WDR4
ArticleAbstract: Chemical modifications of RNA have key roles in many biological processes1–3. N7-methylguanosine (m7Palabras claves:Autores:Arthanari H., Esteban A. Orellana, Fischer E.S., Fontana P., Gregory R.I., Hahn Q., Hunkeler M., Li J., Nowak R.P., Roy Burman S.S., Viennet T., Wang L., Wu H., Yue H.Fuentes:scopusSynthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
ArticleAbstract: Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical prPalabras claves:acute leukemia, asparaginase, asparagine, Drug resistance, FBXW7, GSK3, proteasomal degradation, protein ubiquitination, synthetic lethality, Wnt signalingAutores:Bauer D.E., Degar J., Esteban A. Orellana, Gregory R.I., Gutierrez A., Hinze L., Karim S., McGuckin C., Neuberg D.S., Pfirrmann M., Sacher J., Stanulla M., Stegmaier K., Stevenson K.E., Vinjamur D., Wagner F.F.Fuentes:scopustRNA dysregulation and disease
ReviewAbstract: tRNAs are key adaptor molecules that decipher the genetic code during translation of mRNAs in proteiPalabras claves:Autores:Esteban A. Orellana, Gregory R.I., Siegal E.Fuentes:scopus