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Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin
ArticleAbstract: The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehicPalabras claves:DELIVERY, endosomal escape, folate, folate-conjugates, ligand, microRNA, miR-34, nigericinAutores:Abdelaal A.M., Esteban A. Orellana, Kasinski A.L., Low P.S., Myoung S., Rangasamy L., Tenneti S.Fuentes:scopusIdentification and validation of microRNAs that synergize with miR-34a–a basis for combinatorial microRNA therapeutics
ArticleAbstract: Efforts to search for better treatment options for cancer have been a priority, and due to these effPalabras claves:combinatorial therapeutics, miR-34, miR-34a, miRNA therapeutics, Mirna-34, synergismAutores:Esteban A. Orellana, Kasinski A.L., Li C., Lisevick A.Fuentes:scopusSynthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
ArticleAbstract: Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical prPalabras claves:acute leukemia, asparaginase, asparagine, Drug resistance, FBXW7, GSK3, proteasomal degradation, protein ubiquitination, synthetic lethality, Wnt signalingAutores:Bauer D.E., Degar J., Esteban A. Orellana, Gregory R.I., Gutierrez A., Hinze L., Karim S., McGuckin C., Neuberg D.S., Pfirrmann M., Sacher J., Stanulla M., Stegmaier K., Stevenson K.E., Vinjamur D., Wagner F.F.Fuentes:scopus