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15-Deoxy-Δ<sup>12,14</sup>-prostaglandin-J<inf>2</inf> reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
ArticleAbstract: Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its association to von HiPalabras claves:15-Deoxy-Δ -prostaglandin- J 12,14 2, Calpain, Heat shock protein-90, Hypoxia inducible factor, Lysosome, Proximal tubular cellsAutores:Aragonés J., Arenas M.I., Bienes R., Calzada M.J., Garcia-Bermejo M.L., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G.Fuentes:scopusA yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery
ArticleAbstract: Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, couPalabras claves:Autores:Alcaide-German M.L., Garcia-Fernandez L.F., Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A.Fuentes:scopusAccumulation of hypoxia-inducible factor-1α through a novel electrophilic, thiol antioxidant-sensitive mechanism
ArticleAbstract: 15-deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2) is a peroxisome-activated proliferator receptor-γ (PPARγPalabras claves:15-deoxy-Δ prostaglandin J 12,14 2, Electrophilic, Hypoxia inducible factor, Proximal tubular cells, Reactive oxygen species, Thiol groupsAutores:Arenas I., Castellanos C., Conde I., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G., Peso L.D.Fuentes:scopusEvidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adapPalabras claves:Autores:Alfranca A., Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., San Juan M.A., Vara A., Vidal F.Fuentes:scopusDifferent functional sites on rIFN-α2 and their relation to the cellular receptor binding site
ArticleAbstract: Functional domains on the recombinant interferon-α2 (rIFN-α2) molecule, which are involved in antiviPalabras claves:Autores:Cebrian M., Fresno M., Llamazares S., Manuel Ortiz de Landázuri, Pezzi N., Rodíguez-Moya M., Sánchez‐Madrid F., Yagüe E.Fuentes:scopusMutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma
ArticleAbstract: Inactivation of the von Hippel-Lindau (VHL) tumor suppressor drives the development of clear-cell rePalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Elorza A., Fuertes-Yebra E., Manuel Ortiz de Landázuri, Ordóñez-NavadijoFuentes:scopusHIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5
ArticleAbstract: The mammalian target of rapamycin (mTOR) pathway, which is essential for cell proliferation, is reprPalabras claves:Autores:Acosta-Iborra B., Albacete-Albacete L., Aragonés J., de Cárcer G., Elorza A., Giménez-Bachs J.M., Malumbres M., Manuel Ortiz de Landázuri, Marsboom G., Martín del Río R., Meléndez-Rodríguez F., Ordóñez A., Rodríguez-Vaello V., Salinas A., Sánchez-Prieto R., Sánchez‐Madrid F., Serrano-Oviedo L., Soro-Arnáiz I., Vara-Vega A.Fuentes:scopusInduction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting complex i activity
ArticleAbstract: The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation toPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Cadenas S., Corral-Escariz M., Elorza A., Enríquez J.A., Fuertes-Yebra E., López-Bernardo E., Manuel Ortiz de Landázuri, Martínez-Ruiz A., Ordóñez A., Perales-Clemente E., Soro I., Tello D.Fuentes:scopusUp-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: Role of transcription factor Egr-1
ArticleAbstract: Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and aPalabras claves:Autores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Vidal F.Fuentes:scopus