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B lymphocyte binding to E- and P-selectins is mediated through the de novo expression of carbohydrates on in vitro and in vivo activated human B cells
ArticleAbstract: Cell adhesion to endothelium regulates the trafficking and recruitment of leukocytes towards lymphoiPalabras claves:B lymphocytes, Carbohydrates, integrins, selectin-mediated signaling, selectinsAutores:Manuel Ortiz de Landázuri, Marazuela M., Postigo A.A., Sánchez‐Madrid F.Fuentes:scopusAn in Vivo Functional Immune System Lacking Polyclonal T‐Cell Surface Expression of the CD3/Ti(WT31) Complex
ArticleAbstract: A polyclonal T‐cell receptor complex (TCR) expression defect (as detected with monoclonal antibody WPalabras claves:Autores:ALCAMI J., ARNAIZ‐VILLENA A., CORELL A., López‐Botet M., Manuel Ortiz de Landázuri, MARTIN‐VILLA J.M., REGUEIRO J.R., VICARIO J.L.Fuentes:scopusAnalysis of HIF-prolyl hydroxylases binding to substrates
ArticleAbstract: Hypoxia inducible transcription factors (HIF) are mainly regulated by a group of proline hydroxylasePalabras claves:EGLN, HIF, Hypoxia, PhD, Proline-hydroxylation, VHLAutores:Cuevas Y., Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A., Vitón M.Fuentes:scopus15-Deoxy-Δ<sup>12,14</sup>-prostaglandin-J<inf>2</inf> reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
ArticleAbstract: Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its association to von HiPalabras claves:15-Deoxy-Δ -prostaglandin- J 12,14 2, Calpain, Heat shock protein-90, Hypoxia inducible factor, Lysosome, Proximal tubular cellsAutores:Aragonés J., Arenas M.I., Bienes R., Calzada M.J., Garcia-Bermejo M.L., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G.Fuentes:scopusA novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-γ/δ<sup>+</sup> T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody
ArticleAbstract: In the present study we describe a novel functional cell surface molecule, designated as Kp43, whichPalabras claves:Autores:Acevedo A., Aramburu J., Balboa M.A., López‐Botet M., Manuel Ortiz de Landázuri, Ramirez A., Sánchez‐Madrid F., SILVA A.G.Fuentes:scopusA yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery
ArticleAbstract: Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, couPalabras claves:Autores:Alcaide-German M.L., Garcia-Fernandez L.F., Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A.Fuentes:scopusCD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
ArticleAbstract: CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognatePalabras claves:CD69, HIF-1α, Hypoxia, tumor microenvironment, tumor-infiltrating lymphocytes (TILs)Autores:Aragonés J., Aznar M.Á., Azpilikueta A., Bolaños E., de la Fuente H., Etxeberria I., Garasa S., Labiano S., Maiso P., Manuel Ortiz de Landázuri, Meléndez-Rodríguez F., Melero I., Molina C., Palazón A., Sánchez-Paulete A.R., Sánchez‐Madrid F., Teijeira A.Fuentes:scopusActivators of protein kinase C up-regulate the cell surface expression of CD2 and CD5 T cell glycoproteins
ArticleAbstract: Activation of human T cells through the CD3-T cell receptor complex caused an augmentation in the cePalabras claves:Autores:Alonso M., Cardenas L., Carrera A.C., Manuel Ortiz de Landázuri, Sánchez‐Madrid F., Tugores A.Fuentes:scopusGeneration of T cell blasts with NK-like activity in human MLC: Cellular precursors, IL 2 responsiveness, and phenotype expression
ArticleAbstract: Human MLC were separated after 5 to 7 days of culture by Percoll density gradient centrifugation intPalabras claves:Autores:López‐Botet M., Manuel Ortiz de Landázuri, Rodiguez J., SILVA A.G.Fuentes:scopusExpression of a gp33/27,000 MW activation inducer molecule (AIM) on human lymphoid tissues. Induction of cell proliferation on thymocytes and B lymphocytes by anti-AIM antibodies
ArticleAbstract: We have recently described several monoclonal antibodies (mAb) that recognize a heterodimeric structPalabras claves:Autores:Acevedo A., Cebrian M., López‐Botet M., Manuel Ortiz de Landázuri, Sánchez‐Madrid F., Sánchez‐Mateos P.Fuentes:scopus