Mostrando 10 resultados de: 22
Publisher
PLoS ONE(4)
Journal of Ethnopharmacology(2)
Bioorganic and Medicinal Chemistry Letters(1)
Brain(1)
Brain Communications(1)
Área temáticas
Farmacología y terapéutica(8)
Enfermedades(7)
Bioquímica(6)
Fisiología humana(6)
Fisiología y materias afines(4)
2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes
ArticleAbstract: The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liPalabras claves:2-Octadecynoic acid, Acetylenic fatty acids, Blood stage, Liver stage, MALARIA, plasmodium, Type II fatty acid synthaseAutores:Andricopulo A.D., Bwalya A.G., Carballeira N.M., Crawford A.D., Guido R.V.C., Itoe M.A., Kaiser M., María Lorena Cordero-Maldonado, Mota M.M., Tasdemir D.Fuentes:scopusA phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling
ArticleAbstract: Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation andPalabras claves:Autores:Clements C., Crawford A.D., De Witte P.A.M., Edrada-Ebel R., Esguerra C.V., Gebruers E., Gray A.I., Harvey A.L., María Lorena Cordero-MaldonadoFuentes:rraaescopusTranscriptome profiling data reveals ubiquitin-specific peptidase 9 knockdown effects
OtherAbstract: Ubiquitin specific peptidase 9 (USP9) is a deubiquitinase encoded by a sex-linked gene with a Y-chroPalabras claves:cell culture, Knockdown, Microarray, transcriptomics, Ubiquitin signalingAutores:Antony P., Buttini M., Crawford A.D., Forster J.I., Garcia P., Glaab E., Köglsberger S., María Lorena Cordero-MaldonadoFuentes:scopusl-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain
ArticleAbstract: Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protPalabras claves:Calcium signaling, HT22 cells, isoaspartyl, protein repair, ZebrafishAutores:Clarke S.G., Conrotte J.F., Crawford A.D., Linster C.L., María Lorena Cordero-Maldonado, Martins T.G., Moein M., Skupin A., Soliman R., Warmack R.A.Fuentes:scopusCHD2 variants are a risk factor for photosensitivity in epilepsy
ArticleAbstract: Photosensitivity is a heritable abnormal cortical response to flickering light, manifesting as partiPalabras claves:Eyelid myoclonia with absences, Photosensitive, SeizureAutores:Aarno Palotie, Afrikanova T., Berkovic S.F., Boustred C., Cantonetti L., Capovilla G., Chinthapalli V.K., Coppola A., Covanis A., Crawford A.D., De Kovel C.G.F., Del Gaudio L., Drury S., Esguerra C.V., Galizia E.C., Helbig I., Jacmin M., Jocic-Jakubi B., Koeleman B.P.C., Krause R., Lehesjoki A.E., Lench N., Lerche H., Leu C., María Lorena Cordero-Maldonado, Martins T.G., Mefford H.C., Moller R.S., Muhle H., Mullen S.A., Myers C.T., Nürnberg P., Palotie A., Parisi P., Pendziwiat M., Piccioli M., Ruppert A.K., Sadleir L.G., Sander T., Scheffer I.E., Schneider A.L., Schubert J., Sisodiya S.M., Stephani U., Striano S., Thiele H., Trenité D.G.A.K.N., Veggiotti P.Fuentes:scopusDeep learning image recognition enables efficient genome editing in zebrafish by automated injections
ArticleAbstract: One of the most popular techniques in zebrafish research is microinjection. This is a rapid and effiPalabras claves:Autores:Boland R., Crawford A.D., De Sonneville J., Heins-Marroquin U., María Lorena Cordero-Maldonado, Meijer A.H., Perathoner S., Spaink H.P., Van der Kolk K.J.Fuentes:scopusAnti-inflammatory activity and cheminformatics analysis of new potent 2-substituted 1-methyl-5-nitroindazolinones
ArticleAbstract: After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroiPalabras claves:Anti-inflammatory compound, Nitroindazolinones, SARANEA software, Structure-activity relationship, TPA-induced mouse ear edema, ZebrafishAutores:Andújar I., Arán V.J., Crawford A.D., De Witte P.A.M., Díaz-Mendoza C., Giner R.M., Manjarrez G., María Lorena Cordero-Maldonado, Pérez-Jiménez F., Siverio-Mota D., Veitía Iyarreta M., Veítia M.S.I., Vicet-Muro L., Yovani Marrero-PonceFuentes:scopusAnti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
ArticleAbstract: Ethnopharmacological relevance: Epilepsy is one of the major chronic diseases that does not have a cPalabras claves:Epilepsy, Pleiocarpamine, Rauverine H, Rauvolfia caffra, ZebrafishAutores:Chen W., Chipiti T., Crawford A.D., Enslin G.M., María Lorena Cordero-Maldonado, Sandasi M., Van Heerden F.R., Veale C.G.L., Viljoen A.M.Fuentes:scopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, ZebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Francisco Torrens, Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusGender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies
ArticleAbstract: Public transcriptomic studies have shown that several genes display pronounced gender differences inPalabras claves:Alzheimer's disease, Gender differences, Tau, Tauopathies, transcriptomics, ZebrafishAutores:Antony P., Buttini M., Crawford A.D., Forster J.I., Garcia P., Glaab E., Köglsberger S., María Lorena Cordero-MaldonadoFuentes:scopus