Mostrando 5 resultados de: 5
Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage
ArticleAbstract: A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxicPalabras claves:antiproliferative activity, cell cycle, DNA/RNA damage, Sulfanyl-Sulfinyl-Sulfonyl groups, synthesis of 4-thioalkylquinolineAutores:Bruno-Colmenarez J., Charris J.E., de Sanctis J.B., Deffieux D., Džubák P., Esteban Fernández-Moreira, Gurská S., Gutiérrez J.E., Hajdůch M., Hegira Ramírez, Mijares M.R., Pouységu L., Quideau S., Rodríguez M.A., Rojas L.B.Fuentes:scopusOne-pot multicomponent synthesis of methoxybenzo[h]quinoline-3-carbonitrile derivatives; anti-chagas, X-ray, and in silico ADME/tox profiling studies
ArticleAbstract: Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioPalabras claves:Cáncer, chagas, Methoxybenzo[h]quinoline, One-pot synthesisAutores:Ángel J.E., Capparelli M.V., Charris J.E., Charris K.E., Esteban Fernández-Moreira, Hegira Ramírez, Nogueda-Torres B.Fuentes:scopusSYNTHESIS OF 4-BENZYLSULFANYL AND 4-BENZYLSULFONYL CHALCONES. BIOLOGICAL EVALUATION AS ANTIMALARIAL AGENTS
ArticleAbstract: Malaria management has been complicated in recent times, perhaps, by increasing the Plasmodium spp.Palabras claves:Antimalarial, Chalcones, Plasmodium berghei, β-haematinAutores:Charris J.E., Domínguez J.N., Esteban Fernández-Moreira, Hegira Ramírez, Rodrigues J.R., Rodríguez M.A.Fuentes:scopusSynthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity
ArticleAbstract: A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment or a 2-amPalabras claves:2-Aminoindane, Chloroquine, Hemozoin, MALARIA, β-PhenethylamineAutores:Ángel J.E., Charris J.E., Esteban Fernández-Moreira, Hegira Ramírez, Mijares M.R., Rodrigues J.R.Fuentes:scopusSynthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives
ArticleAbstract: The coexistence of leishmaniasis, Chagas disease, and neoplasia in endemic areas has been extensivelPalabras claves:apoptosis, Cáncer, chalcone, leishmaniasis, TRYPANOSOMA CRUZIAutores:Ángel J.E., Blanco Z., Celis C., Charris J.E., de Sanctis J.B., Džubák P., Esteban Fernández-Moreira, García Y., Gurská S., Hajdůch M., Hegira Ramírez, Jhonny Correa-Abril, Martinez G.P., Mijares M.R., Mijoba A., Nahum Herrera, Serrano X., Yonathan De J. ParraFuentes:scopus